Evidence map›Paper›PMID 35387040›Full record

ArticleFrontiers in allergy2021

Virtual Reality Reduces Pediatric Anxiety During Food Allergy Clinical Trials: A Pilot Randomized, Pragmatic Study.

Sarah Alonzi, Thomas J Caruso, Sayantani B Sindher, Shu Cao, Sara Varadharajulu, William J Collins, R Sharon Chinthrajah

Open access · goldAbstract read
In one paragraph

Article in Frontiers in allergy, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.0field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 7 citations in OpenAlex.

  1. Effectiveness of virtual reality in reducing anxiety, fear, and pain in children undergoing skin prick testing: A crossover study.Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology · 2025
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  2. Review
  3. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Sarah AlonziDepartment of Psychology, University of California, Los Angeles, Los Angeles, CA, United States.
Thomas J CarusoDepartment of Anesthesiology, Perioperative, and Pain Medicine, Stanford University School of Medicine, Stanford, CA, United States.
Sayantani B SindherSean N. Parker Center for Allergy and Asthma Research at Stanford University, Stanford University, Stanford, CA, United States.
Shu CaoSean N. Parker Center for Allergy and Asthma Research at Stanford University, Stanford University, Stanford, CA, United States.
Sara VaradharajuluDepartment of Medicine, University of California San Francisco School of Medicine, San Francisco, CA, United States.
William J CollinsSean N. Parker Center for Allergy and Asthma Research at Stanford University, Stanford University, Stanford, CA, United States.
R Sharon ChinthrajahSean N. Parker Center for Allergy and Asthma Research at Stanford University, Stanford University, Stanford, CA, United States.
Stanford University · USUniversity of California, Los Angeles · USUniversity of California, San Francisco · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Phlebotomy procedures required in food allergy (FA) diagnosis and clinical trials often induce fear and anxiety for pediatric patients. The primary aim of this study was to determine whether virtual reality (VR) applications were effective in reducing anxiety for pediatric FA patients undergoing phlebotomy during FA clinical trials. Secondary aims assessed fear, pain, procedural compliance, and adverse events. Participants undergoing phlebotomy were enrolled and randomized to a VR group or standard of care (SOC) group for this prospective pilot randomized, pragmatic study. Participants in the VR group played interactive applications on a customized Samsung Gear VR headset and those in the SOC group received the standard of care. Participants' anxiety, fear, and pain were assessed with the Children's Anxiety Meter, Children's Fear Scale, and FACES pain scale pre, during, and post phlebotomy procedure. Compliance was assessed using the modified Induction Compliance Checklist during the procedure and compared between two groups. Forty-nine participants were randomized to VR (

Indexed as

anxietyfearfood allergypainphlebotomyvirtual reality

Identifiers

PMID35387040
PMCPMC8974765
OpenAlexW4205535044

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.