Evidence map›Paper›PMID 35387039›Full record

ReviewFrontiers in allergy2021

The Nose as a Route for Therapy: Part 1. Pharmacotherapy.

Cemal Cingi, Nuray Bayar Muluk, Dimitrios I Mitsias, Nikolaos G Papadopoulos, Ludger Klimek, Anu Laulajainen-Hongisto, Maija Hytönen, Sanna Katriina Toppila-Salmi, Glenis Kathleen Scadding

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Frontiers in allergy, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 2 pooled it
2.1field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 2 syntheses or guidelines pooled it, 28 citations in OpenAlex.

  1. Pooled it
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  9. Opposing effects of acellular and whole cell pertussis vaccines onbioRxiv : the preprint server for biology · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 7 institutions in 5 countries.

Cemal CingiDepartment of Otolaryngology, Eskişehir Osmangazi University, Eskişehir, Turkey.
Nuray Bayar MulukDepartment of Otolaryngology, Kirikkale University, Kirikkale, Turkey.
Dimitrios I MitsiasAllergy Department, 2nd Pediatric Clinic, National and Kapodistrian University of Athens, Athens, Greece.
Nikolaos G PapadopoulosAllergy Department, 2nd Pediatric Clinic, National and Kapodistrian University of Athens, Athens, Greece.
Ludger KlimekCentre for Rhinology and Allergology, Wiesbaden, Germany.
Anu Laulajainen-HongistoDepartment of Otorhinolaryngology-Head and Neck Surgery, Helsinki University Hospital, Helsinki, Finland.
Maija HytönenDepartment of Otorhinolaryngology-Head and Neck Surgery, Helsinki University Hospital, Helsinki, Finland.
Sanna Katriina Toppila-SalmiSkin and Allergy Hospital, Helsinki University Central Hospital, Helsinki, Finland.
Glenis Kathleen ScaddingUniversity College London Hospitals NHS Foundation Trust, London, United Kingdom.
Helsinki University Hospital · FINational and Kapodistrian University of Athens · GREskişehir Osmangazi University · TRKırıkkale University · TRRoyal National Throat Nose and Ear Hospital · GBUniversity of Helsinki · FIZentrum für Rhinologie und Allergologie · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This article reviews nasal structure and function in the light of intranasal pharmacotherapy. The nose provides an accessible, fast route for local treatment of nose and sinus diseases, with lower doses than are necessary systemically and few adverse effects. It can also be used for other medications as it has sufficient surface area protected from local damage by mucociliary clearance, absence of digestive enzymes, responsive blood flow, and provides a rapid route to the central nervous system.

Indexed as

allergic rhinitischronic rhinosinusitisdrug deliveryintranasal routelysine aspirinmucociliary clearancenasal epitheliumsaline douche

Identifiers

PMID35387039
PMCPMC8974766
OpenAlexW3129824812

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.