Evidence map›Paper›PMID 35386985›Full record

ArticleFrontiers in allergy2021

Antigen Uptake After Intradermal Microinjection Depends on Antigen Nature and Formulation, but Not on Injection Depth.

Romain J T Leboux, Pim Schipper, Toni M M van Capel, Lily Kong, Koen van der Maaden, Alexander Kros, Wim Jiskoot, Esther C de Jong, Joke A Bouwstra

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in allergy, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.5field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 7 citations in OpenAlex.

  1. Review
  2. Article
  3. Self-amplifying RNA vaccine protects mice against lethal Ebola virus infection.Molecular therapy : the journal of the American Society of Gene Therapy · 2023
    Article
  4. Immunology of allergen immunotherapy.Immunotherapy advances · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 2 countries.

Romain J T LebouxDivision of BioTherapeutics, Leiden Academic Centre for Drug Research, Leiden University, Leiden, Netherlands.
Pim SchipperDivision of BioTherapeutics, Leiden Academic Centre for Drug Research, Leiden University, Leiden, Netherlands.
Toni M M van CapelDepartment of Experimental Immunology, Academic Medical Center, Amsterdam, Netherlands.
Lily KongDivision of Supramolecular Chemistry, Leiden Institute of Chemistry, Leiden University, Leiden, Netherlands.
Koen van der MaadenTumor Immunology Group, Department of Immunology, Leiden University Medical Center, Leiden, Netherlands.
Alexander KrosDivision of Supramolecular Chemistry, Leiden Institute of Chemistry, Leiden University, Leiden, Netherlands.
Wim JiskootDivision of BioTherapeutics, Leiden Academic Centre for Drug Research, Leiden University, Leiden, Netherlands.
Esther C de JongDepartment of Experimental Immunology, Academic Medical Center, Amsterdam, Netherlands.
Joke A BouwstraDivision of BioTherapeutics, Leiden Academic Centre for Drug Research, Leiden University, Leiden, Netherlands.
Leiden University · NLAcademic Medical Center · NLCentre for Human Drug Research · NLLeiden University Medical Center · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The skin is an attractive alternative administration route for allergy vaccination, as the skin is rich in dendritic cells (DCs) and is easily accessible. In the skin multiple subsets of DCs with distinct roles reside at different depths. In this study antigen (=allergen for allergy) formulations were injected in

Indexed as

allergen specific immunotherapyantigen uptakeBet v 1injection depthintradermal injectionliposomesovalbumin

Identifiers

PMID35386985
PMCPMC8974696
OpenAlexW3154394347

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.