ReviewFrontiers in allergy2021
Abundance and Stability as Common Properties of Allergens.
Review in Frontiers in allergy, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
39 citing papers in PubMed.
- Proteomic Mapping of Allergenic Proteins Reveals Key Differences Between Black Tiger Prawn (Journal of proteome research · 2026Article
- Protein quality and allergenicity assessment of chia seeds (Frontiers in toxicology · 2026Article
- Assessment of genetically modified soybean MON 94313 (application GMFF-2022-6595).EFSA journal. European Food Safety Authority · 2026Article
- Optimising Extraction of Specific Food Allergens from Challenging Food Matrices for Immunoassay Quantification.Foods (Basel, Switzerland) · 2025Article
- Assessment of genetically modified soybean MON 94637 (application GMFF-2023-21116).EFSA journal. European Food Safety Authority · 2025Article
- Assessment of genetically modified sugar beet KWS20-1 (application GMFF-2023-14732).EFSA journal. European Food Safety Authority · 2025Article
- Assessment of genetically modified maize DAS1131 (application GMFF-2021-1530).EFSA journal. European Food Safety Authority · 2025Article
- Enhancing allergenicity risk assessment for novel foods in the EU: insights from the updated EFSA guidance - requirements, knowledge gaps and research needs.Frontiers in toxicology · 2025Review
- Analysis of allergen positivity rates in relation to gender, age, and cross-reactivity patterns.Scientific reports · 2024Article
- Assessment of genetically modified maize MON 95275 (application GMFF-2022-5890).EFSA journal. European Food Safety Authority · 2024Article
- Assessment of genetically modified maize DP910521 (application GMFF-2021-2473).EFSA journal. European Food Safety Authority · 2024Article
- Assessment of genetically modified maize DP202216 for food and feed uses, under Regulation (EC) No 1829/2003 (application EFSA-GMO-NL-2019-159).EFSA journal. European Food Safety Authority · 2024Article
- Proteomic analysis of horse hair extracts provides no evidence for the existence of a hypoallergenic Curly Horse breed.Clinical and translational allergy · 2024Article
- Peanut allergen characterization and allergenicity throughout development.Frontiers in allergy · 2024Article
- Assessment of genetically modified maize DP23211 for food and feed uses, under Regulation (EC) No 1829/2003 (application EFSA-GMO-NL-2019-163).EFSA journal. European Food Safety Authority · 2024Article
- Research gaps and future needs for allergen prediction in food safety.Frontiers in allergy · 2024Review
- Spatiotemporal proteolytic susceptibility of allergens: positive or negative effects on the allergic sensitization?Frontiers in allergy · 2024Review
- Assessment of genetically modified maize DP915635 for food and feed uses, under regulation (EC) No 1829/2003 (application EFSA-GMO-NL-2020-172).EFSA journal. European Food Safety Authority · 2024Article
- Albumin Proteins as Delivery Vehicles for PFAS Contaminants into Respiratory Membranes.ACS omega · 2023Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
There have been many attempts to identify common biophysical properties which differentiate allergens from their non-immunogenic counterparts. This review will focus on recent studies which examine two such factors: abundance and stability. Anecdotal accounts have speculated that the elevated abundance of potential allergens would increase the likelihood of human exposure and thus the probability of sensitization. Similarly, the stability of potential allergens dictates its ability to remain a viable immunogen during the transfer from the source to humans. This stability could also increase the resilience of potential allergens to both gastric and endosomal degradation, further skewing the immune system toward allergy. Statistical analyses confirm both abundance and stability as common properties of allergens, while epidemiological surveys show a correlation between exposure levels (abundance) and allergic disease. Additional studies show that changes in protein stability can predictably alter gastric/endosomal processing and immunogenicity, providing a mechanistic link between stability and allergenicity. However, notable exceptions exist to both hypotheses which highlight the multifaceted nature of immunological sensitization, and further inform our understanding of some of these other factors and their contribution to allergic disease.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.