ArticleEnvironment international2022
Quantitative non-targeted analysis: Bridging the gap between contaminant discovery and risk characterization.
Article in Environment international, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
49 citing papers in PubMed.
- The exposome and inflammatory bowel disease: a framework for primary and primordial prevention.Nature reviews. Gastroenterology & hepatology · 2026Review
- Integrating Suspect and Nontargeted Screening for Food Safety Testing: A Case Study of Bee Pollen Supplements.Analytical chemistry · 2026Article
- In-Depth Analysis of the Data from an Interlaboratory Study of Quantitative Non-Target Screening-How Do the Instrumental Methods Compare?Molecules (Basel, Switzerland) · 2026Article
- Non-Targeted Analysis Workflow of Endocrine-Disrupting Chemicals in Ovarian Follicular Fluid: Identification of Parabens by Diagnostic Fragmentation Evidence and Additional Contaminants via Mass Spectral Library Matching.ACS measurement science au · 2025Article
- Suspect screening of bisphenol A (BPA) structural analogues and functional alternatives in human milk from Canada and South Africa.Journal of exposure science & environmental epidemiology · 2025Article
- Examining the effects of analytical replication on data quality in a non-targeted analysis experiment.Analytical and bioanalytical chemistry · 2025Article
- Examining structure-based surrogate selection for quantitative non-targeted analysis.Analytical and bioanalytical chemistry · 2025Article
- Perfluorinated carbon chain length drives uptake of diverse Per- and polyfluoroalkyl substances in field-deployed passive samplers.ACS ES&T water · 2025Article
- The application of PTR-MS and non-targeted analysis to characterize VOCs emitted from a plastic recycling facility fire.Journal of exposure science & environmental epidemiology · 2025Article
- Examining environmental matrix effects on quantitative non-targeted analysis estimates of per- and polyfluoroalkyl substances.Analytical and bioanalytical chemistry · 2025Article
- Automated QA/QC reporting for non-targeted analysis: a demonstration of "INTERPRET NTA" with de facto water reuse data.Analytical and bioanalytical chemistry · 2025Article
- A paradigm shift in environmental monitoring - The time for non-targeted analysis (NTA) is now.Environment international · 2025Article
- Emerging Per- and Polyfluoroalkyl Substances in Tap Water from the American Healthy Homes Survey II.Environmental science & technology · 2025Article
- Communicating with Stakeholders to Identify High-Impact Research Directions for Non-Targeted Analysis.Analytical chemistry · 2025Review
- A Comprehensive Antioxidant and Nutritional Profiling of Brassicaceae Microgreens.Antioxidants (Basel, Switzerland) · 2025Article
- Environmental Applications of Mass Spectrometry for Emerging Contaminants.Molecules (Basel, Switzerland) · 2025Review
- A Semi-Quantitative Approach to Nontarget Compositional Analysis of Complex Samples.Analytical chemistry · 2024Article
- Quantification Approaches in Non-Target LC/ESI/HRMS Analysis: An Interlaboratory Comparison.Analytical chemistry · 2024Article
- Streamlining Phenotype Classification and Highlighting Feature Candidates: A Screening Method for Non-Targeted Ion Mobility Spectrometry-Mass Spectrometry (IMS-MS) Data.Analytical chemistry · 2024Article
- Combined screening and retroactive data mining for emerging perfluoroethers in wildlife and pets in the Cape Fear region of North Carolina.Chemosphere · 2024Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
Chemical risk assessments follow a long-standing paradigm that integrates hazard, dose-response, and exposure information to facilitate quantitative risk characterization. Targeted analytical measurement data directly support risk assessment activities, as well as downstream risk management and compliance monitoring efforts. Yet, targeted methods have struggled to keep pace with the demands for data regarding the vast, and growing, number of known chemicals. Many contemporary monitoring studies therefore utilize non-targeted analysis (NTA) methods to screen for known chemicals with limited risk information. Qualitative NTA data has enabled identification of previously unknown compounds and characterization of data-poor compounds in support of hazard identification and exposure assessment efforts. In spite of this, NTA data have seen limited use in risk-based decision making due to uncertainties surrounding their quantitative interpretation. Significant efforts have been made in recent years to bridge this quantitative gap. Based on these advancements, quantitative NTA data, when coupled with other high-throughput data streams and predictive models, are poised to directly support 21st-century risk-based decisions. This article highlights components of the chemical risk assessment process that are influenced by NTA data, surveys the existing literature for approaches to derive quantitative estimates of chemicals from NTA measurements, and presents a conceptual framework for incorporating NTA data into contemporary risk assessment frameworks.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.