Evidence map›Paper›PMID 35386920›Full record

ArticleFrontiers in medicine2022

Diagnostic Performance of Rapid Antigen Testing for SARS-CoV-2: The COVid-19 AntiGen (COVAG) study.

Christoph Wertenauer, Geovana Brenner Michael, Alexander Dressel, Caroline Pfeifer, Ulrike Hauser, Eberhard Wieland, Christian Mayer, Caren Mutschmann, Martin Roskos, Hans-Jörg Wertenauer and 3 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 1 pooled it
2.4field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 1 synthesis or guideline pooled it, 24 citations in OpenAlex.

  1. Rapid, point-of-care antigen tests for diagnosis of SARS-CoV-2 infection.The Cochrane database of systematic reviews · 2025
    Pooled it
  2. Vitamin DFrontiers in oral health · 2026
    Trial
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 5 institutions in 3 countries.

Christoph WertenauerHausärzte am Schillerplatz, Stuttgart, Germany.
Geovana Brenner MichaelSYNLAB Holding Deutschland GmbH, Augsburg, Germany.
Alexander DresselDr. Dressel Consulting, Mannheim, Germany.
Caroline PfeiferSYNLAB Holding Deutschland GmbH, Augsburg, Germany.
Ulrike HauserSYNLAB Medical Care Center Augsburg GmbH, Augsburg, Germany.
Eberhard WielandSYNLAB Medical Care Center Leinfelden-Echterdingen GmbH, Leinfelden-Echterdingen, Germany.
Christian MayerSYNLAB Holding Deutschland GmbH, Augsburg, Germany.
Caren MutschmannSGS Analytics Germany GmbH, Berlin, Germany.
Martin RoskosSYNLAB Holding Deutschland GmbH, Augsburg, Germany.
Hans-Jörg WertenauerHausärzte am Schillerplatz, Stuttgart, Germany.
Angela P MoisslMedical Clinic V, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany.
Stefan LorkowskiInstitute of Nutritional Sciences, Friedrich Schiller University Jena, Jena, Germany.
Winfried MärzMedical Clinic V, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany.
Synlab (Germany) · DEClimate Analytics · DEFriedrich Schiller University Jena · DEUniversity Hospital Heidelberg · DEUniversity Medical Centre Mannheim · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Rapid diagnostic testing for SARS-Cov-2 antigens is used to combat the ongoing pandemic. In this study we aimed to compare two RDTs, the SD Biosensor Q SARS-CoV-2 Rapid Antigen Test (Roche) and the Panbio COVID-19 Ag Rapid Test (Abbott), against rRT-PCR. Methods: We included 2,215 all-comers at a diagnostic center between February 1 and March 31, 2021. rRT-PCR-positive samples were examined for SARS-CoV-2 variants. Findings: Three hundred and thirty eight participants (15%) were rRT-PCR-positive for SARS-CoV-2. The sensitivities of Roche-RDT and Abbott-RDT were 60.4 and 56.8% ( Interpretation: The sensitivities of the two RDTs for asymptomatic SARS-CoV-2 carriers are unsatisfactory. Their widespread use may not be effective in the ongoing SARS-CoV-2 pandemic. The virus genotype influences the sensitivity of the two RDTs. RDTs should be evaluated for different SARS-CoV-2 variants.

Indexed as

antigen testingCOVID-19diagnostic performancerapid detectionSARS-CoV-2sensitivityvariants

Identifiers

PMID35386920
PMCPMC8979030
OpenAlexW4220896837

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.