ArticleNature photonics2019
Optical coherence refraction tomography.
Article in Nature photonics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
32 citing papers in PubMed.
- Physics-informed deep learning enables reliable and scalable organoid quantification for drug screening via OCT.NPJ digital medicine · 2026Article
- Volumetric montaging of optical coherence tomography in human retinas.bioRxiv : the preprint server for biology · 2026Article
- Noninvasive photoacoustic computed mesoscopy for longitudinal brain imaging.Science advances · 2026Article
- Label-free full-thickness imaging of porcine vagus nerve fascicular anatomy by polarization-sensitive optical coherence tomography.Journal of neural engineering · 2025Article
- Computational approach for correcting defocus and suppressing speckle noise in line-field optical coherence tomography images.Biomedical optics express · 2024Article
- Visualization of CONature chemistry · 2024Article
- Ultrasound-induced reorientation for multi-angle optical coherence tomography.Nature communications · 2024Article
- Correcting spatial-spectral crosstalk and chromatic aberrations in broadband line-scan spectral-domain OCT images.Biomedical optics express · 2023Article
- Three-dimensional imaging and quantification of mouse ovarian follicles via optical coherence tomography.Biomedical optics express · 2023Article
- In-silico clearing approach for deep refractive index tomography by partial reconstruction and wave-backpropagation.Light, science & applications · 2023Article
- Optical trapping with holographically structured light for single-cell studies.Biophysics reviews · 2023Review
- On the inverse problem in optical coherence tomography.Scientific reports · 2023Article
- Three-dimensional bi-functional refractive index and fluorescence microscopy (BRIEF).Biomedical optics express · 2022Article
- Skin cancer margin detection using nanosensitive optical coherence tomography and a comparative study with confocal microscopy.Biomedical optics express · 2022Article
- Flexible method for generating needle-shaped beams and its application in optical coherence tomography.Optica · 2022Article
- Article
- Video-rate high-precision time-frequency multiplexed 3D coherent ranging.Nature communications · 2022Article
- Towards standardizing retinal optical coherence tomography angiography: a review.Light, science & applications · 2022Review
- Metasurface-based bijective illumination collection imaging provides high-resolution tomography in three dimensions.Nature photonics · 2022Article
- Multiple-scattering suppressive refractive index tomography for the label-free quantitative assessment of multicellular spheroids.Biomedical optics express · 2022Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
Optical coherence tomography (OCT) is a cross-sectional, micron-scale imaging modality with widespread clinical application. Typical OCT systems sacrifice lateral resolution to achieve long depths of focus for bulk tissue imaging, and hence tend to have better axial than lateral resolution. Such anisotropic resolution can obscure fine ultrastructural features. Furthermore, conventional OCT suffers from refraction-induced image distortions. Here, we introduce optical coherence refraction tomography (OCRT), which extends the superior axial resolution to the lateral dimension, synthesising undistorted cross-sectional image reconstructions from multiple conventional images acquired with angular diversity. In correcting refraction-induced distortions to register the OCT images, OCRT also achieves spatially resolved refractive index imaging. We demonstrate >3-fold improvement in lateral resolution as well as speckle reduction in imaging tissue ultrastructure, consistent with histology. With further optimisation in optical designs to incorporate angular diversity into clinical instruments, OCRT could be widely applied as an enhancement over conventional OCT.
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.