ArticleFrontiers in immunology2022
Systemic Immune-Inflammation Index Is Associated With Increased Urinary Albumin Excretion: A Population-Based Study.
Article in Frontiers in immunology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 133 papers, 2 of them syntheses that pooled it.
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Who cites it
133 citing papers in PubMed, 2 syntheses or guidelines pooled it, 194 citations in OpenAlex.
- Neuroimaging Insights into the Public Health Burden of Neuropsychiatric Disorders: A Systematic Review of Electroencephalography-Based Cognitive Biomarkers.Medicina (Kaunas, Lithuania) · 2025Pooled it
- The association between anti-inflammatory therapies and renal outcomes in patients with established cardiovascular disease or high cardiovascular risks: a meta-analysis of randomised controlled trials.Inflammopharmacology · 2025Pooled it
- Article
- The Impact of Severe Albuminuria on the Proinflammatory Monocyte Subset CD14++CD16+ and Antigen-Specific Immune Responses.International journal of molecular sciences · 2026Article
- Association of urinary albumin-to-creatinine ratio with all-cause and cardiovascular disease mortality risk in patients with osteoarthritis: a prospective cohort study.Clinical rheumatology · 2026Article
- Systemic immune-inflammation index as a risk factor for acute kidney injury in patients with neonatal jaundice.Translational pediatrics · 2026Article
- Controlling nutritional status score as a novel prognostic tool for hospital mortality risk stratification in sepsis: a large-scale retrospective cohort analysis.BMC infectious diseases · 2026Article
- Article
- Relationship between inflammatory indicators and bone mineral density in preschool children.Pediatric research · 2026Article
- LDL-C modifies the association between triglycerides and depression identified by threshold scanning in US adults.Scientific reports · 2026Article
- Article
- Association between malnutrition risk and diabetic nephropathy in adult patients with type 2 diabetes: a cross-sectional study and mediation analysis.BMC endocrine disorders · 2026Article
- Associations between neutrophil-to-high-density lipoprotein cholesterol ratio and albuminuria: A cross-sectional study.The Journal of international medical research · 2026Article
- Systemic inflammation and B cell indices predict rituximab responses in membranous nephropathy.Clinical kidney journal · 2026Article
- Associations of metabolic indicators and inflammation-related indices with adverse cardiovascular events in US adults: NHANES 1999-2018.Lipids in health and disease · 2026Article
- Analysis of correlated factors of skin pruritus in type 2 diabetes mellitus.BMC endocrine disorders · 2026Observational
- Systemic immune-inflammation index as a novel biomarker for predicting surgical site infection in people living with HIV: a multicenter, retrospective cohort study.Frontiers in cellular and infection microbiology · 2026Observational
- Correlation between serum prolactin and the systemic immune-inflammation index in diabetic kidney disease: a cross-sectional study.Frontiers in endocrinology · 2026Article
- Association of BRI With Psoriasis and Mediator Effect of SII: A Study Based on NHANES (2003-2006, 2009-2014).Mediators of inflammation · 2026Article
- Prognostic Value of Systemic Immune-Inflammation Index (SII) in Hospital Readmission Following Acute Myocardial Infarction: A Four-Year Analysis.Cardiology research and practice · 2026Article
73 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Systemic immune-inflammation index (SII) is a novel inflammatory marker, and inflammation has been reported to be related with renal damage. We aimed to investigate the possible relationship between SII and albuminuria. Methods: The present cross-sectional study was conducted among adults with complete data about SII and urinary albumin-to-creatinine ratio (ACR) in 2005-2018 National Health and Nutrition Examination Survey (NHANES). SII was calculated as the platelet count × neutrophil count/lymphocyte count. Albuminuria was defined as ACR >30mg/g. Weighted multivariable regression analysis and subgroup analysis were conducted to explore the independent relationship between SII and albuminuria. Results: A total of 36,463 individuals were included in our analysis; 9.56% participants were categorized as having albuminuria overall and increased with the higher SII tertiles (tertile 1, 7.83%; tertile 2, 8.49%; tertile 3, 12.13%; p for trend <0.0001). Multivariable logistic regression showed that a higher SII level was associated with increased likelihood of albuminuria independently (OR = 1.31; 95% CI, 1.17-1.48, p<0.0001) after full adjustment. Subgroup analysis and interaction test showed that there was no significant dependence of gender, age, body mass index, hypertension, diabetes, non-alcoholic fatty liver disease, and estimated glomerular filtration rate (eGFR) on this positive association (all p for interaction >0.05). Conclusions: SII was positively associated with increased urinary albumin excretion in US adults. Further large-scale prospective studies are still needed to analyze the role of SII in albuminuria.
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