ArticleKidney medicine2022
Cystatin C- and Creatinine-Based Glomerular Filtration Rate Estimation Differences and Muscle Quantity and Functional Status in Older Adults: The Health, Aging, and Body Composition Study.
Article in Kidney medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
26 citing papers in PubMed, 2 syntheses or guidelines pooled it, 46 citations in OpenAlex.
- Discordance in Creatinine- and Cystatin C-Based eGFR and Clinical Outcomes: A Meta-Analysis.JAMA · 2025Pooled it
- Pooled it
- Simple Bedside Muscle-Related Indicators Improve the Identification of Reduced Kidney Function in Hospitalized Older Adults: A Multicenter Cross-Sectional Study.Geriatrics & gerontology international · 2026Article
- Evaluating Long-Term Outcomes Across eGFR Equations in Older Adults.Kidney international reports · 2026Article
- Association Between Differences in Estimated GFR by Creatinine Vs. Cystatin C and Stroke Outcomes: Results From the Third China National Stroke Registry.CNS neuroscience & therapeutics · 2026Article
- The difference between cystatin C- and creatinine-based estimated glomerular filtration rate and survival in amyotrophic lateral sclerosis: a population-based cohort study.Neurodegenerative disease management · 2026Article
- Article
- Indirect estimates of cellular hydration and relative water content and their associations with muscle strength and physical function in older adults: a path analysis from the Pro-Eva study.European review of aging and physical activity : official journal of the European Group for Research into Elderly and Physical Activity · 2026Article
- Article
- Using the Difference Between Estimated Glomerular Filtration Rate by Cystatin C and Creatinine to Improve Mortality Risk Prediction in Elderly Patients With CKD in the HUNT Study.Kidney medicine · 2026Article
- Difference between cystatin C- and creatinine-based estimated glomerular filtration rate and incident hypertension and the mediating role of Triglyceride Glucose Index.Renal failure · 2025Article
- Biomarkers and Clinical Evaluation in the Detection of Frailty.International journal of molecular sciences · 2025Review
- Comparing Cystatin C Estimated GFR With Creatinine Estimated GFR in Acute Kidney Injury Recovery.Kidney international reports · 2025Article
- Complex Etiologies of the Discordance Between Cystatin C- and Creatinine-Based Estimated GFR and Its Adverse Associations: Findings From the CRIC Study.American journal of kidney diseases : the official journal of the National Kidney Foundation · 2025Article
- F2-Isoprostanes Are Associated With Increased Fracture Risk in Type 2 Diabetes.The Journal of clinical endocrinology and metabolism · 2025Observational
- Different ways of diagnosing selective glomerular hypofiltration syndromes such as shrunken pore syndrome and the associated increase in mortality.Journal of internal medicine · 2025Article
- Development and internal validation of an age less-dependent frailty score in the cardiovascular health study.Frontiers in medicine · 2025Article
- Diagnostic Power of Serum Creatinine/Cystatin C Ratio for Identifying Low MRI-Muscle Volume and Low Grip Strength: Data From 9 731 to 149 707 UK Biobank Older Adults.The journals of gerontology. Series A, Biological sciences and medical sciences · 2024Observational
- Difference between kidney function by cystatin C versus creatinine and association with muscle mass and frailty.Journal of the American Geriatrics Society · 2024Article
- Large Discordance between Creatinine-Based and Cystatin C-Based eGFRs is Associated with Falls, Hospitalizations, and Death in Older Adults.Clinical journal of the American Society of Nephrology : CJASN · 2024Article
Corrections and comments
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Authors and funding
7 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Rationale & Objective: The difference in the estimated glomerular filtration rate based on cystatin C and that based on creatinine (eGFRDiff) is known to be associated with frailty and mortality. Creatinine is influenced by muscle mass, more so than cystatin C; we aimed to determine whether eGFRDiff is associated with muscle quantity and to what extent muscle quantity explains the relationship between eGFRDiff and poor functional status. Study Design: A cohort analysis of the health, aging, and body composition study (HABC). Setting & Participants: Overall, 2,970 HABC participants had their baseline serum creatinine level, cystatin C level, and body composition measured using imaging. Exposure: Estimated glomerular filtration rates (eGFRs) were calculated using Chronic Kidney Disease Epidemiology Collaboration equations (estimated glomerular filtration rate based on cystatin C [eGFR Outcomes: The total thigh muscle area was evaluated using computed tomography. The health, aging, and body composition study physical performance battery was scored on a continuous scale (standing and walking tasks); poor functional status was characterized by the lowest quartile. Analytical Approach: We used linear regression to model the cross-sectional association of eGFRDiff and muscle measures. We used logistic regression to evaluate the association of eGFRDiff with poor functional status. Results: The mean age was 74 ± 3 years; the eGFR Limitations: The functional status outcome was specific to HABC. The muscle measures did not capture dynamic turnover. Conclusions: The difference of eGFR
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