Evidence map›Paper›PMID 35386550›Full record

ArticleCurrent opinion in biomedical engineering2022

Computational Biomechanical Modeling of Fibrin Networks and Platelet-Fiber Network Interactions.

Francesco Pancaldi, Oleg V Kim, John W Weisel, Mark Alber, Zhiliang Xu

Open access · greenAbstract read
In one paragraph

Article in Current opinion in biomedical engineering, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
2.3field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 15 citations in OpenAlex.

  1. Review
  2. Rupture mechanics of blood clot fibrin fibers: A coarse-grained model study.Journal of the mechanics and physics of solids · 2025
    Article
  3. Article
  4. Decoding thrombosis through code: a review of computational models.Journal of thrombosis and haemostasis : JTH · 2024
    Review
  5. Article
  6. Review
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Francesco PancaldiDepartment of Mathematics, University of California Riverside, Riverside, CA 92505, USA.
Oleg V KimDepartment of Cell and Developmental Biology, University of Pennsylvania School of Medicine, Philadelphia, PA, 19104, USA.
John W WeiselDepartment of Cell and Developmental Biology, University of Pennsylvania School of Medicine, Philadelphia, PA, 19104, USA.
Mark AlberDepartment of Mathematics, University of California Riverside, Riverside, CA 92505, USA.
Zhiliang XuDepartment of Applied and Computational Mathematics and Statistics, University of Notre Dame, IN 46556, USA.
University of California, Riverside · USUniversity of Pennsylvania · USUniversity of Notre Dame · US

Funding

Multiscale modeling and empirical study of a mechanism limiting blood clot growthU01HL116330 · NHLBI · UNIVERSITY OF NOTRE DAME · PI ALBER, MARK · 2014 to 2018
$3.5M
Multiscale structural and functional biomechanics of contracting platelet-fibrin based biomaterials and blood clots in oral microenvironmentR21DE030294 · NIDCR · VIRGINIA POLYTECHNIC INST AND ST UNIV · PI KIM, OLEG · 2021 to 2022
$447k
American Heart Association-American Stroke Association 17SDG33680177NHLBI NIH HHS U01 HL116330NIDCR NIH HHS R21 DE030294
6 · The paper itself

Abstract

Fibrin deformation and interaction of fibrin with other blood components play critical roles in hemostasis and thrombosis. In this review, computational and mathematical biomechanical models of fibrin network deformation and contraction at different spatio-temporal scales as well as challenges in developing and calibrating multiscale models are discussed. There are long standing challenges. For instance, applicability of models to identify and test potential mechanisms of the biomechanical processes mediating interactions between platelets and fiber networks in blood clot stretching and contraction needs to be examined carefully. How the structural and mechanical properties of major blood clot components influences biomechanical responses of the entire clot subjected to external forces, such as blood flow or vessel wall deformations needs to be investigated thoroughly.

Indexed as

blood clotComputational modelcontractiondeformationfibrin mechanicshemostasisplateletthrombosisthrombus

Identifiers

PMID35386550
PMCPMC8979495
OpenAlexW4212769303

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.