Evidence map›Paper›PMID 35386472›Full record

ArticleAlzheimer's & dementia (Amsterdam, Netherlands)2022

Cortical atrophy and amyloid and tau deposition in Down syndrome: A longitudinal study.

Concepcion Padilla, Victor Montal, Madeleine J Walpert, Young T Hong, Tim D Fryer, Jonathan P Coles, Franklin I Aigbirhio, Sigan L Hartley, Ann D Cohen, Dana L Tudorascu and 5 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Alzheimer's & dementia (Amsterdam, Netherlands), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.6field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 13 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Article
  6. Characterizing the emergence of amyloid and tau burden in Down syndrome.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024
    Article
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 4 institutions in 5 countries.

Concepcion PadillaCambridge Intellectual and Developmental Disabilities Research Group, Department of Psychiatry University of Cambridge Cambridge UK.ORCID https://orcid.org/0000-0003-4102-6787
Victor MontalMemory Unit and Biomedical Research Institute Sant Pau (IIB Sant Pau), Neurology Department Santa Creu and Sant Pau Hospital Barcelona Spain.
Madeleine J WalpertCambridge Intellectual and Developmental Disabilities Research Group, Department of Psychiatry University of Cambridge Cambridge UK.
Young T HongWolfson Brain Imaging Centre, Department of Clinical Neurosciences, Cambridge Biomedical Campus University of Cambridge Cambridge UK.
Tim D FryerWolfson Brain Imaging Centre, Department of Clinical Neurosciences, Cambridge Biomedical Campus University of Cambridge Cambridge UK.
Jonathan P ColesDivision of Anaesthesia, Department of Medicine, Cambridge Biomedical Campus University of Cambridge Cambridge UK.
Franklin I AigbirhioWolfson Brain Imaging Centre, Department of Clinical Neurosciences, Cambridge Biomedical Campus University of Cambridge Cambridge UK.
Sigan L HartleyWaisman Center University of Wisconsin-Madison Madison Wisconsin USA.
Ann D CohenDepartment of Psychiatry University of Pittsburgh Pittsburgh Pennsylvania USA.
Dana L TudorascuDepartment of Psychiatry University of Pittsburgh Pittsburgh Pennsylvania USA.
Bradley T ChristianWaisman Center University of Wisconsin-Madison Madison Wisconsin USA.
Benjamin L HandenDepartment of Psychiatry University of Pittsburgh Pittsburgh Pennsylvania USA.
William E KlunkDepartment of Psychiatry University of Pittsburgh Pittsburgh Pennsylvania USA.
Anthony J HollandCambridge Intellectual and Developmental Disabilities Research Group, Department of Psychiatry University of Cambridge Cambridge UK.
Shahid H ZamanCambridge Intellectual and Developmental Disabilities Research Group, Department of Psychiatry University of Cambridge Cambridge UK.
University of Cambridge · GBUniversity of Pittsburgh · USUniversity of Wisconsin–Madison · USHospital de Sant Pau · ES

Funding

Project 3: Biomarkers for DS Clinical TrialsU19AG068054 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI TUDORASCU, DANA L · 2020 to 2025
$103.7M
NiAD Supplement WashU Start UpU01AG051406 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI CHRISTIAN, BRADLEY T, HANDEN, BENJAMIN L · 2015 to 2019
$21.3M
Natural History of Amyloid Deposition in Adults with Down SyndromeR01AG031110 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI HANDEN, BENJAMIN L · 2009 to 2016
$5.2M
Medical Research Council MR/K02308X/1NIA NIH HHS R01 AG031110NIA NIH HHS U01 AG051406NIA NIH HHS U19 AG068054
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Alzheimer's diseaseamyloid depositioncortical atrophyDown syndromelongitudinaltau deposition

Identifiers

PMID35386472
PMCPMC8974205
OpenAlexW4226375056

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.