Evidence map›Paper›PMID 35386438›Full record

ArticleBioactive materials2022

A self-crosslinking, double-functional group modified bacterial cellulose gel used for antibacterial and healing of infected wound.

Yajie Xie, Kun Qiao, Lina Yue, Tao Tang, Yudong Zheng, Shihui Zhu, Huiyi Yang, Ziyuan Fang

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Bioactive materials, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
11.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 108 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Yajie XieSchool of Material Science and Engineering, University of Science and Technology Beijing, Beijing, China.
Kun QiaoSchool of Material Science and Engineering, University of Science and Technology Beijing, Beijing, China.
Lina YueHebei Key Laboratory of Hazardous Chemicals Safety and Control Technology, School of Chemical and Environmental Engineering, North China Institute of Science and Technology, Langfang, 065201, Hebei, China.
Tao TangDepartment of Burn Surgery, The First Affiliated Hospital of Naval Medical University, Shanghai, 200433, China.
Yudong ZhengSchool of Material Science and Engineering, University of Science and Technology Beijing, Beijing, China.
Shihui ZhuDepartment of Burn Surgery, The First Affiliated Hospital of Naval Medical University, Shanghai, 200433, China.
Huiyi YangSchool of Material Science and Engineering, University of Science and Technology Beijing, Beijing, China.
Ziyuan FangSchool of Material Science and Engineering, University of Science and Technology Beijing, Beijing, China.
University of Science and Technology Beijing · CNNorth China Institute of Science and Technology · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cellulose/chitosan composite, as a mature commercial antibacterial dressing, is an important type of wound repair material. However, how to achieve the perfect compound of two components and improve antibacterial activity is a major, lingering issue. In this study, a bifunctional group modified bacterial cellulose (DCBC) was prepared by carboxymethylation and selective oxidation. Further, the chitosan (CS) was compounded in the network of DCBC by self-crosslinking to form dialdehyde carboxymethyl bacterial cellulose/chitosan composites (S-DCBC/CS). The aldehyde group can react with amino of CS by Schiff base reaction. The carboxyl group of DCBC and the amorphous distribution of CS molecular chains increase the antimicrobial properties of composites. The bacteriostatic rate of composites could be higher than 95%. Bacteria can be attracted onto the surface of composites, what we call it "directional adhesion antibacterial effects". In particular, a kind of large animal wound model, deep Ⅱ degree infected scald of Bama miniature pig, was used to research the antimicrobial and healing properties of materials. The S-DCBC/CS can effectively inhibit bacterial proliferation of wound and kill the bacteria. The wound healing rate of S-DCBC/CS was up to 80% after three weeks. The composites show better antibacterial and promoting concrescence effects than traditional chitosan dressings.

Indexed as

Antimicrobial propertiesBacterial celluloseCell migrationSelf-crosslinkingWound healing

Identifiers

PMID35386438
PMCPMC8965089
OpenAlexW4205947363

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.