ArticleReproductive medicine and biology
A gene network of uterine luminal epithelium organizes mouse blastocyst implantation.
Article in Reproductive medicine and biology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 30 citations in OpenAlex.
- Embryonic Mediators of Embryo-Uterus Communication, Implantation and Pregnancy.Molecular reproduction and development · 2026Review
- Divergent selection for litter size variability affects RNA cargo in oviductal extracellular vesicles related to embryonic development and survival.Biological research · 2025Article
- A bovine 3D endometrium-on-a-chip reveals the role of conceptus-derived proteins, CAPG and PDI, in conceptus-endometrial communication.Biology of reproduction · 2025Article
- Establishment of an in vitro implantation model using a newly developed mouse endometrial organoid.Development (Cambridge, England) · 2025Article
- Phospholipid flippase ATP11A brokers uterine epithelial integrity and function.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Identifying Significant SNPs of the Total Number of Piglets Born and Their Relationship with Leg Bumps in Pigs.Biology · 2024Article
- Spatiotemporal functions of leukemia inhibitory factor in embryo attachment and implantation chamber formation.Cell death discovery · 2024Article
- Attenuated retinoic acid signaling is among the early responses in mouse uterus approaching embryo attachment.Reproductive and developmental medicine · 2024Article
- Article
- Single-cell insights into epithelial morphogenesis in the neonatal mouse uterus.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Identification and characterization of circRNAs in peri-implantation endometrium between Yorkshire and Erhualian pigs.BMC genomics · 2023Article
- The EZH2-PRC2-H3K27me3 axis governs the endometrial cell cycle and differentiation for blastocyst invasion.Cell death & disease · 2023Article
- Proteomic profiles and the function of RBP4 in endometrium during embryo implantation phases in pigs.BMC genomics · 2023Article
- Article
- A gene network of uterine luminal epithelium organizes mouse blastocyst implantation.Reproductive medicine and biologyArticle
- Toward Implantation-Assisting Technologies: Lessons From In Vivo and Ex Vivo Models.Reproductive medicine and biologyReview
Corrections and comments
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Authors and funding
11 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Purpose: The receptive endometrium is critical for blastocyst implantation. In mice, after blastocysts enter the uterine cavities on day 4 of pregnancy (day 1 = vaginal plug), blastocyst attachment is completed within 24 h, accompanied by dynamic interactions between the uterine luminal epithelium and the blastocysts. Any failures in this process compromise subsequent pregnancy outcomes. Here, we performed comprehensive analyses of gene expression at the luminal epithelium in the peri-implantation period. Methods: RNA-seq combined with laser microdissection (LMD) was used to reveal unique gene expression kinetics in the epithelium. Results: We found that the prereceptive epithelium on day 3 specifically expresses cell cycle-related genes. In addition, days 3 and 4 epithelia express glutathione pathway-related genes, which are protective against oxidative stresses. In contrast, day 5 epithelium expresses genes involved in glycolysis and the regulation of cell proliferation. The genes highly expressed on days 3 and 4 compared to day 5 are related to progesterone receptor signaling, and the genes highly expressed on day 5 compared to days 3 and 4 are associated with the ones regulated by H3K27me3. Conclusions: These results suggest that specific gene expression patterns govern uterine functions during early pregnancy, contributing to implantation success.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.