ArticleReproductive medicine and biology
NDRG1 is expressed in human granulosa cells: An implicative role of NDRG1 in the ovary.
Article in Reproductive medicine and biology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 13 citations in OpenAlex.
- Integrated single-cell and metabolomic profiling identifies ovarian metabolic differences and endothelial heterogeneity associated with litter-size variation in Hu sheep.Journal of animal science and biotechnology · 2026Article
- The impact of hypoxia on the cellular phenotype and proteome of KGN cells.Reproduction & fertility · 2025Article
- Effects of cigarette smoke extract on angiogenesis and aromatase activity in KGN cells.Scientific reports · 2025Article
- HIF-1α Promotes Luteinization via NDRG1 Induction in the Human Ovary.Biomedicines · 2025Article
- Article
- Transcriptomic thermal plasticity underlying gonadal development in a turtle with ZZ/ZW sex chromosomes despite canalized genotypic sex determination.Ecology and evolution · 2023Article
- Identification of potential angiogenic biomarkers in human follicular fluid for predicting oocyte maturity.Frontiers in endocrinology · 2023Article
- NDRG1 is expressed in human granulosa cells: An implicative role of NDRG1 in the ovary.Reproductive medicine and biologyArticle
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Purpose: N-myc downstream-regulated gene 1 (NDRG1) is expressed in various human tissues and plays a role in regulating cellular proliferation, angiogenesis, and hypoxia sensing. However, the role of NDRG1 in the ovary remains poorly understood. Therefore, we investigated NDRG1 expression and the role of NDRG1 in the human ovary. Methods: Follicular fluid (FF) and luteinized granulosa cells were collected from follicles during oocyte retrieval. KGN cells were cultured with cobalt chloride (CoCl Results: NDRG1 protein was expressed in luteinized granulosa cells. NDRG1 concentration was positively correlated with vascular endothelial growth factor (VEGF) and progesterone concentrations in FF. CoCl Conclusions: These results indicate that ovarian NDRG1 may play important roles in follicular development, especially in the early luteinization of pre-ovulatory follicles.
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