Evidence map›Paper›PMID 35386344›Full record

ArticleBioactive materials2022

Dual-functional porous and cisplatin-loaded polymethylmethacrylate cement for reconstruction of load-bearing bone defect kills bone tumor cells.

Zhule Wang, Liebert Parreiras Nogueira, Håvard Jostein Haugen, Ingrid Cm Van Der Geest, Patricia Caetano de Almeida Rodrigues, Dennis Janssen, Thom Bitter, Jeroen J J P van den Beucken, Sander Cg Leeuwenburgh

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Bioactive materials, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
1.4field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 28 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 2 countries.

Zhule WangRadboud University Medical Center, Department of Dentistry - Regenerative Biomaterials, Radboud Institute for Molecular Life Sciences, Nijmegen, the Netherlands.
Liebert Parreiras NogueiraUniversity of Oslo, Department of Biomaterials, Institute of Clinical Dentistry, Faculty of Dentistry, Oslo, Norway.
Håvard Jostein HaugenUniversity of Oslo, Department of Biomaterials, Institute of Clinical Dentistry, Faculty of Dentistry, Oslo, Norway.
Ingrid Cm Van Der GeestRadboud University Medical Center, Department of Orthopedics, Radboud Institute for Health Sciences, Nijmegen, the Netherlands.
Patricia Caetano de Almeida RodriguesRadboud University Medical Center, Department of Orthopedics, Radboud Institute for Health Sciences, Nijmegen, the Netherlands.
Dennis JanssenRadboud University Medical Center, Department of Orthopedics, Radboud Institute for Health Sciences, Nijmegen, the Netherlands.
Thom BitterRadboud University Medical Center, Department of Orthopedics, Radboud Institute for Health Sciences, Nijmegen, the Netherlands.
Jeroen J J P van den BeuckenRadboud University Medical Center, Department of Dentistry - Regenerative Biomaterials, Radboud Institute for Molecular Life Sciences, Nijmegen, the Netherlands.
Sander Cg LeeuwenburghRadboud University Medical Center, Department of Dentistry - Regenerative Biomaterials, Radboud Institute for Molecular Life Sciences, Nijmegen, the Netherlands.
Radboud University Nijmegen · NLUniversity of Oslo · NO

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Malignant bone tumors are usually treated by resection of tumor tissue followed by filling of the bone defect with bone graft substitutes. Polymethylmethacrylate (PMMA) cement is the most commonly used bone substitute in clinical orthopedics in view of its reliability. However, the dense nature of PMMA renders this biomaterial unsuitable for local delivery of chemotherapeutic drugs to limit the recurrence of bone tumors. Here, we introduce porosity into PMMA cement by adding carboxymethylcellulose (CMC) to facilitate such local delivery of chemotherapeutic drugs, while retaining sufficient mechanical properties for bone reconstruction in load-bearing sites. Our results show that the mechanical strength of PMMA-based cements gradually decreases with increasing CMC content. Upon incorporation of ≥3% CMC, the PMMA-based cements released up to 18% of the loaded cisplatin, in contrast to cements containing lower amounts of CMC which only released less than 2% of the cisplatin over 28 days. This release of cisplatin efficiently killed osteosarcoma cells

Indexed as

Bone tumor treatmentChemotherapeutic drugEx vivo biomechanical assessmentLocal drug deliveryPorous polymethylmethacrylate cement

Identifiers

PMID35386344
PMCPMC8941180
OpenAlexW4200475467

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.