ArticleBioactive materials2022
Responsive and self-healing structural color supramolecular hydrogel patch for diabetic wound treatment.
Article in Bioactive materials, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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Who cites it
33 citing papers in PubMed, 74 citations in OpenAlex.
- Advances in Structural Colors-Mechanisms, Quantitative Evaluation, and Applications: A Review.Nanomaterials (Basel, Switzerland) · 2026Review
- Advances in 3D Printed Bone Implants: Smart Responsive Antibacterial Strategies and AI-Driven Design.Biomimetics (Basel, Switzerland) · 2026Review
- Biocompatible Self-Healing Hydrogel for VAT 3D Printing.ACS materials Au · 2026Article
- High drug-loaded supramolecular microgels enabled by controlled in-droplet self-assembly for adaptive treatment of inflammatory arthritis.Bioactive materials · 2026Article
- Hydrogel-Flexible Electronics Integrated Platforms for Diabetic Wound Management.Materials (Basel, Switzerland) · 2026Review
- Stimuli-responsive hydrogels based on cascade reactions: a novel strategy to promote the efficient repair of diabetic wounds.Theranostics · 2026Review
- Bioinspired Real-Time Dynamic Responsive Structural Colors.Polymer science & technology (Washington, D.C.) · 2025Review
- Intelligent hydrogel-based dressings for treatment of chronic diabetic wounds.World journal of diabetes · 2025Review
- Glucose oxidase: An emerging multidimensional treatment option for diabetic wound healing.Bioactive materials · 2025Review
- Advances in smart stimuli-responsive materials for oral wound healing.Frontiers in chemistry · 2025Review
- Application and development of stimulus-responsive hydrogel biomaterials for diabetic wound healing: a literature review.Frontiers in medicine · 2025Review
- Microenvironment-responsive peptide hydrogels: molecular mechanisms, design and frontiers.Frontiers in bioengineering and biotechnology · 2025Review
- Innovations in hydrogel therapies for diabetic wound healing: bridging the gap between pathophysiology and clinical application.Burns & trauma · 2025Review
- A supramolecular hydrogel leveraging hierarchical multi-strength hydrogen-bonds hinged strategy achieving a striking adhesive-mechanical balance.Bioactive materials · 2025Article
- Bioactive peptides and proteins for tissue repair: microenvironment modulation, rational delivery, and clinical potential.Military Medical Research · 2024Review
- Review
- Islet cell spheroids produced by a thermally sensitive scaffold: a new diabetes treatment.Journal of nanobiotechnology · 2024Article
- Advances in Smart-Response Hydrogels for Skin Wound Repair.Polymers · 2024Review
- Advances in tumor vascular growth inhibition.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2024Review
- Advancements and Challenges in Self-Healing Hydrogels for Wound Care.Gels (Basel, Switzerland) · 2024Review
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The treatment of diabetic wounds remains a great challenge for medical community. Here, we present a novel structural color supramolecular hydrogel patch for diabetic wound treatment. This hydrogel patch was created by using N-acryloyl glycinamide (NAGA) and 1-vinyl-1,2,4-triazole (VTZ) mixed supramolecular hydrogel as the inverse opal scaffold, and temperature responsive poly(N-isopropylacrylamide) (PNIPAM) hydrogel loaded with vascular endothelial cell growth factor (VEGF) as a filler. Supramolecular hydrogel renders hydrogel patch with superior mechanical properties, in which NAGA and VTZ also provide self-healing and antibacterial properties, respectively. Besides, as the existence of PNIPAM, the hydrogel patch was endowed with thermal-responsiveness property, which could release actives in response to temperature stimulus. Given these excellent performances, we have demonstrated that the supramolecular hydrogel patch could significantly enhance the wound healing process in diabetes rats by downregulating the expression of inflammatory factors, promoting collagen deposition and angiogenesis. Attractively, due to responsive optical property of inverse opal scaffold, the hydrogel patch could display color-sensing behavior that was suitable for the wound monitoring and management as well as guidance of clinical treatment. These distinctive features indicate that the presented hydrogel patches have huge potential values in biomedical fields.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.