Evidence map›Paper›PMID 35386337›Full record

ReviewBioactive materials2022

The influence of nanotopography on cell behaviour through interactions with the extracellular matrix - A review.

Jiajun Luo, Matthew Walker, Yinbo Xiao, Hannah Donnelly, Matthew J Dalby, Manuel Salmeron-Sanchez

Open access · goldAbstract readReview
In one paragraph

Review in Bioactive materials, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 68 papers.

0numbers the graph read from it
0cells of the map it votes in
68citing papers in PubMed
10.1field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

68 citing papers in PubMed, 146 citations in OpenAlex.

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8 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Jiajun LuoCentre for the Cellular Microenvironment, University of Glasgow, Glasgow, G12 8LT, UK.
Matthew WalkerCentre for the Cellular Microenvironment, University of Glasgow, Glasgow, G12 8LT, UK.
Yinbo XiaoCentre for the Cellular Microenvironment, University of Glasgow, Glasgow, G12 8LT, UK.
Hannah DonnellyCentre for the Cellular Microenvironment, University of Glasgow, Glasgow, G12 8LT, UK.
Matthew J DalbyCentre for the Cellular Microenvironment, University of Glasgow, Glasgow, G12 8LT, UK.
Manuel Salmeron-SanchezCentre for the Cellular Microenvironment, University of Glasgow, Glasgow, G12 8LT, UK.
University of Glasgow · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Nanotopography presents an effective physical approach for biomaterial cell manipulation mediated through material-extracellular matrix interactions. The extracellular matrix that exists in the cellular microenvironment is crucial for guiding cell behaviours, such as determination of integrin ligation and interaction with growth factors. These interactions with the extracellular matrix regulate downstream mechanotransductive pathways, such as rearrangements in the cytoskeleton and activation of signal cascades. Protein adsorption onto nanotopography strongly influences the conformation and distribution density of extracellular matrix and, therefore, subsequent cell responses. In this review, we first discuss the interactive mechanisms of protein physical adsorption on nanotopography. Secondly, we summarise advances in creating nanotopographical features to instruct desired cell behaviours. Lastly, we focus on the cellular mechanotransductive pathways initiated by nanotopography. This review provides an overview of the current state-of-the-art designs of nanotopography aiming to provide better biomedical materials for the future.

Indexed as

BiomaterialsCell-material interactionNanotopographyProtein adsorption

Identifiers

PMID35386337
PMCPMC8940943
OpenAlexW4200160480

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.