ArticleBioactive materials2022
Slow degrading Mg-based materials induce tumor cell dormancy on an osteosarcoma-fibroblast coculture model.
Article in Bioactive materials, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07395219 (Prospective Evaluation of the Safety and Efficacy of Transoral Incisionless Fundoplication 2.0 in the Management of Reflux), which is not on this map. Cited by 15 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Prospective Evaluation of the Safety and Efficacy of Transoral Incisionless Fundoplication 2.0 in the Management of Reflux: a European Registry
Who cites it
15 citing papers in PubMed, 23 citations in OpenAlex.
- Immunomodulatory effects of biodegradable Mg-Cu-Zn alloy in esophageal cancer.Bioactive materials · 2026Article
- Targeting tumor dormancy: the next frontier in gastrointestinal stromal tumor therapy.Neoplasia (New York, N.Y.) · 2026Review
- A promising magnesium-related alloy with metabolic reprogramming and antitumor effects in hepatocellular and pancreatic cancer.Bioactive materials · 2026Article
- MnOMaterials today. Bio · 2026Article
- Biodegradable magnesium-calcium mineralized collagen metal materials inhibits invasion and metastasis of osteosarcoma.Scientific reports · 2025Article
- The Recent Developments of Thermomechanical Processing for Biomedical Mg Alloys and Their Clinical Applications.Materials (Basel, Switzerland) · 2025Review
- Research Progress of Magnesium Alloys and Its Alloys in Medical Applications.International journal of general medicine · 2025Review
- Study on the role and mechanism of magnesium-calcium-mineralized collagen composite scaffolds in the adjuvant treatment of cervical cancer.Regenerative biomaterials · 2025Article
- Exploring the frontiers: The potential and challenges of bioactive scaffolds in osteosarcoma treatment and bone regeneration.Materials today. Bio · 2024Review
- Concerting magnesium implant degradation facilitates local chemotherapy in tumor-associated bone defect.Bioactive materials · 2024Article
- Hierarchical Hybrid Coatings with Drug-Eluting Capacity for Mg Alloy Biomaterials.Materials (Basel, Switzerland) · 2023Article
- Microstructure, Mechanical Properties, In Vitro Biodegradability, and Biocompatibility of Mg-Zn/HA Composites for Biomedical Implant Applications.Materials (Basel, Switzerland) · 2023Article
- In Vitro and In Vivo Applications of Magnesium-Enriched Biomaterials for Vascularized Osteogenesis in Bone Tissue Engineering: A Review of Literature.Journal of functional biomaterials · 2023Review
- Review
- Mg-based materials diminish tumor spreading and cancer metastases.Bioactive materials · 2023Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Osteosarcoma is one of the most common cancers in young adults and is commonly treated using surgery and chemotherapy. During the past years, these therapy approaches improved but failed to ameliorate the outcomes. Therefore, novel, targeted therapeutic approaches should be established to enhance treatment success while preserving patient's quality of life. Recent studies suggest the application of degradable magnesium (Mg) alloys as orthopedic implants bearing a potential antitumor activity. Here, we examined the influence of Mg-based materials on an osteosarcoma-fibroblast coculture. Both, Mg and Mg-6Ag did not lead to tumor cell apoptosis at low degradation rates. Instead, the Mg-based materials induced cellular dormancy in the cancer cells indicated by a lower number of Ki-67 positive cancer cells and a higher p38 expression. This dormancy-like state could be reversed by reseeding on non-degrading glass slides but could not be provoked by inhibition of the protein kinase R-like endoplasmic reticulum kinase. By investigating the influence of the disjunct surface-near effects of the Mg degradation on cell proliferation, an increased pH was found to be a main initiator of Mg degradation-dependent tumor cell proliferation inhibition.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.