Evidence map›Paper›PMID 35386316›Full record

ArticleBioactive materials2022

Antibiofilm and immunomodulatory resorbable nanofibrous filing for dental pulp regenerative procedures.

Mauricio Gonçalves da Costa Sousa, Gabriela Conceição de Almeida, Danilo César Martins Mota, Rosiane Andrade da Costa, Simoni Campos Dias, Samuel Nunes Limberger, Frank Ko, Li Ting Lin, Evan F Haney, Hashem Etayash and 12 more

Abstract read
In one paragraph

Article in Bioactive materials, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed.

  1. Article
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  7. Article
  8. Antibiotic failure: Beyond antimicrobial resistance.Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy · 2023
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors.

Mauricio Gonçalves da Costa SousaPost-Graduation Program in Genomic Sciences and Biotechnology, Catholic University of Brasília, Brasília, Brazil.
Gabriela Conceição de AlmeidaDentistry Course, Catholic University of Brasília, Brasília, Brazil.
Danilo César Martins MotaPost-Graduation Program in Health Sciences, University of Brasília, Brazil.
Rosiane Andrade da CostaPost-Graduation Program in Genomic Sciences and Biotechnology, Catholic University of Brasília, Brasília, Brazil.
Simoni Campos DiasPost-Graduation Program in Genomic Sciences and Biotechnology, Catholic University of Brasília, Brasília, Brazil.
Samuel Nunes LimbergerLIMA, Chemistry Institute, University of Brasília-UNB, Brasília, Brazil.
Frank KoDepartment of Materials Engineering, Faculty of Applied Science, University of British Columbia, Vancouver, Canada.
Li Ting LinDepartment of Materials Engineering, Faculty of Applied Science, University of British Columbia, Vancouver, Canada.
Evan F HaneyDepartment of Microbiology and Immunology, University of British Columbia, Vancouver, BC, Canada.
Hashem EtayashDepartment of Microbiology and Immunology, University of British Columbia, Vancouver, BC, Canada.
Beverlie BaquirDepartment of Microbiology and Immunology, University of British Columbia, Vancouver, BC, Canada.
Michael J TrimbleDepartment of Microbiology and Immunology, University of British Columbia, Vancouver, BC, Canada.
Ya ShenDepartment of Oral Biological and Medical Sciences, Faculty of Dentistry, University of British Columbia, Vancouver, Canada.
Zheng SuDepartment of Oral Biological and Medical Sciences, Faculty of Dentistry, University of British Columbia, Vancouver, Canada.
Markus HaapasaloDepartment of Oral Biological and Medical Sciences, Faculty of Dentistry, University of British Columbia, Vancouver, Canada.
Daniel PletzerDepartment of Microbiology and Immunology, University of Otago, Dunedin, New Zealand.
Letícia Chaves de SouzaDepartment of Endodontics, School of Dentistry, University of Texas Health Science Center at Houston, Houston, USA.
Gláucia Schuindt TeixeiraDepartment of Endodontics, School of Dentistry, University of Texas Health Science Center at Houston, Houston, USA.
Renato M SilvaDepartment of Endodontics, School of Dentistry, University of Texas Health Science Center at Houston, Houston, USA.
Robert E W HancockDepartment of Microbiology and Immunology, University of British Columbia, Vancouver, BC, Canada.
Octavio Luiz FrancoPost-Graduation Program in Genomic Sciences and Biotechnology, Catholic University of Brasília, Brasília, Brazil.
Taia Maria Berto RezendePost-Graduation Program in Genomic Sciences and Biotechnology, Catholic University of Brasília, Brasília, Brazil.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Multifunctional scaffolds with host defense peptides designed for regenerative endodontics are desirable nanobiotechnological tools for dentistry. Here, different scaffolds were tested for use during the pulp revascularization process, including poly(vinyl alcohol)-PVA hydrogels or resins, collagen hydrogels and poly(vinyl alcohol) PVA/Chitosan (PVA/CS) nanofibers. Based on time to degradation (21 days), nanofibers were chosen to be incorporated with ciprofloxacin and IDR-1002 (each at 50 mg/g). Nanofibers containing ciprofloxacin and IDR-1002 had anti-biofilm activity against

Indexed as

CiprofloxacinHost defense peptidesIDR-1002NanofibersRegenerative endodonticsScaffolds

Identifiers

PMID35386316
PMCPMC8965695

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.