ArticleInfection and drug resistance2022
Introduction of Probiotic-Based Sanitation in the Emergency Ward of a Children's Hospital During the COVID-19 Pandemic.
Article in Infection and drug resistance, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it, 23 citations in OpenAlex.
- Human microbiome and microbiota identification for preventing and controlling healthcare-associated infections: A systematic review.Frontiers in public health · 2022Pooled it
- Comparative Metagenomic Studies Reveal Different Evolutionary Directions of Synthetic Indoor Microbial Communities Under Different Nutritional Conditions.International journal of molecular sciences · 2026Article
- Antimicrobial Peptides as Next-Generation Disinfectants: Tackling Biocide and Antimicrobial Resistance in Hospital Hygiene - A Narrative Review.Probiotics and antimicrobial proteins · 2026Review
- Probiotic-Based Cleaning Solutions: From Research Hypothesis to Infection Control Applications.Biology · 2025Review
- Probiotic-Based Approaches for Sustainable Control of Infectious Risk in Mass Transport: Current Data and Future Perspectives.Microbial biotechnology · 2025Review
- Targeted next-generation sequencing enhances precision and rapid detection in healthcare-associated infection Surveillance: Unveiling multidrug-resistant colonization in ICUs.New microbes and new infections · 2025Article
- Profiling the resistome and virulome of Bacillus strains used for probiotic-based sanitation: a multicenter WGS analysis.BMC genomics · 2025Article
- Can probiotics trigger a paradigm shift for cleaning healthcare environments? A narrative review.Antimicrobial resistance and infection control · 2024Review
- Tackling transmission of infectious diseases: A probiotic-based system as a remedy for the spread of pathogenic and resistant microbes.Microbial biotechnology · 2024Review
- Biocontrol in built environments to reduce pathogen exposure and infection risk.The ISME journal · 2024Review
- A critical assessment of microbial-based antimicrobial sanitizing of inanimate surfaces in healthcare settings.Frontiers in microbiology · 2024Review
- Characterization of the Pathogenic Potential of the Beach Sand Microbiome and Assessment of Quicklime as a Remediation Tool.Microorganisms · 2023Article
- [Health Technology Assessment of the introduction of the Probiotic Cleaning Hygiene System (PCHS) in the Italian healthcare setting: update].Journal of preventive medicine and hygiene · 2023Article
- ESKAPEE Pathogen Biofilm Control on Surfaces with ProbioticAntibiotics (Basel, Switzerland) · 2023Review
- Article
- Potential Use of a Combined Bacteriophage-Probiotic Sanitation System to Control Microbial Contamination and AMR in Healthcare Settings: A Pre-Post Intervention Study.International journal of molecular sciences · 2023Article
- Shaping the subway microbiome through probiotic-based sanitation during the COVID-19 emergency: a pre-post case-control study.Microbiome · 2023Article
- The impact of COVID-19 on multidrug-resistant organisms causing healthcare-associated infections: a narrative review.JAC-antimicrobial resistance · 2023Review
- The Gut Microbiome of Children during the COVID-19 Pandemic.Microorganisms · 2022Review
- The Microbiome of the Built Environment: The Nexus for Urban Regeneration for the Cities of Tomorrow.Microorganisms · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Antimicrobial resistance (AMR) represents a major threat to public health, especially in the hospital environment, and the massive use of disinfectants to prevent COVID-19 transmission might intensify this risk, possibly leading to future AMR pandemics. However, the control of microbial contamination is crucial in hospitals, since hospital microbiomes can cause healthcare-associated infections (HAIs), which are particularly frequent and severe in pediatric wards due to children having high susceptibility. Aim: We have previously reported that probiotic-based sanitation (PCHS) could stably decrease pathogens and their AMR in the hospital environment, reduce associated HAIs in adult hospitals, and inactivate enveloped viruses. Here, we aimed to test the effect of PCHS in the emergency room (ER) of a children's hospital during the COVID-19 pandemic. Methods: Conventional chemical disinfection was replaced by PCHS for 2 months during routine ER sanitation; the level of environmental bioburden was characterized before and at 2, 4, and 9 weeks after the introduction of PCHS. Microbial contamination was monitored simultaneously by conventional culture-based CFU count and molecular assays, including 16S rRNA NGS for bacteriome characterization and microarrays for the assessment of the resistome of the contaminating population. The presence of SARS-CoV-2 was also monitored by PCR. Results and conclusions: PCHS usage was associated with a stable 80% decrease in surface pathogens compared to levels detected for chemical disinfection (
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.