ArticleComputational toxicology (Amsterdam, Netherlands)2022
Comparing the performance and coverage of selected
Article in Computational toxicology (Amsterdam, Netherlands), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 29 citations in OpenAlex.
- Structure-Property Associations: Breaking Paradigms for Linking Chemical Structures and Biological Properties in Drug Discovery.ChemMedChem · 2026Article
- Building a compendium of expert driven read-across cases to facilitate an analysis of the contribution that different similarity contexts play in read-across performance.Computational toxicology (Amsterdam, Netherlands) · 2025Article
- Guidance on the use of read-across for chemical safety assessment in food and feed.EFSA journal. European Food Safety Authority · 2025Article
- Can graph similarity metrics be helpful for analogue identification as part of a read-across approach?Computational toxicology (Amsterdam, Netherlands) · 2025Article
- Metabolism study of two phenethylamine - derived new psychoactive substances using in silico, in vivo, and in vitro approaches.Archives of toxicology · 2025Article
- Evaluation of Violacein Metabolic Stability and Metabolite Identification in Human, Mouse, and Rat Liver Microsomes.Pharmaceutics · 2025Article
- The TOXIN knowledge graph: supporting animal-free risk assessment of cosmetics.Database : the journal of biological databases and curation · 2025Article
- Molecular similarity in chemical informatics and predictive toxicity modeling: from quantitative read-across (q-RA) to quantitative read-across structure-activity relationship (q-RASAR) with the application of machine learning.Critical reviews in toxicology · 2024Review
- A systematic analysis of read-across within REACH registration dossiers.Computational toxicology (Amsterdam, Netherlands) · 2024Article
- MetSim: Integrated Programmatic Access and Pathway Management for Xenobiotic Metabolism Simulators.Chemical research in toxicology · 2024Article
- Screening for drinking water contaminants of concern using an automated exposure-focused workflow.Journal of exposure science & environmental epidemiology · 2024Article
- Quantifying Analogue Suitability for SAR-Based Read-Across Toxicological Assessment.Chemical research in toxicology · 2023Article
- Towards systematic read-across using Generalised Read-Across (GenRA).Computational toxicology (Amsterdam, Netherlands) · 2023Article
- Advancing the science of a read-across framework for evaluation of data-poor chemicals incorporating systematic and new approach methods.Regulatory toxicology and pharmacology : RTP · 2023Article
- Identifying xenobiotic metabolites withFrontiers in toxicology · 2023Article
- Human-Based New Approach Methodologies in Developmental Toxicity Testing: A Step Ahead from the State of the Art with a Feto-Placental Organ-on-Chip Platform.International journal of environmental research and public health · 2022Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
Changes in the regulatory landscape of chemical safety assessment call for the use of New Approach Methodologies (NAMs) including read-across to fill data gaps. One critical aspect of analogue evaluation is the extent to which target and source analogues are metabolically similar. In this study, a set of 37 structurally diverse chemicals were compiled from the EPA ToxCast inventory to compare and contrast a selection of metabolism
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.