Evidence map›Paper›PMID 35386217›Full record

ArticleBrain communications2022

Neuroanatomical correlations of visuospatial processing in primary progressive aphasia.

Boon Lead Tee, Christa Watson Pereira, Sladjana Lukic, Lynn P Bajorek, Isabel Elaine Allen, Zachary A Miller, Kaitlin B Casaletto, Bruce L Miller, Maria Luisa Gorno-Tempini

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Brain communications, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Boon Lead TeeMemory and Aging Center, University of California at San Francisco, San Francisco, CA, USA.ORCID https://orcid.org/0000-0003-2217-3466
Christa Watson PereiraMemory and Aging Center, University of California at San Francisco, San Francisco, CA, USA.
Sladjana LukicMemory and Aging Center, University of California at San Francisco, San Francisco, CA, USA.
Lynn P BajorekMemory and Aging Center, University of California at San Francisco, San Francisco, CA, USA.
Isabel Elaine AllenDepartment of Epidemiology and Biostatistics, University of California, San Francisco, CA, USA.
Zachary A MillerMemory and Aging Center, University of California at San Francisco, San Francisco, CA, USA.ORCID https://orcid.org/0000-0002-5991-3053
Kaitlin B CasalettoMemory and Aging Center, University of California at San Francisco, San Francisco, CA, USA.ORCID https://orcid.org/0000-0003-0610-6933
Bruce L MillerMemory and Aging Center, University of California at San Francisco, San Francisco, CA, USA.
Maria Luisa Gorno-TempiniMemory and Aging Center, University of California at San Francisco, San Francisco, CA, USA.

Funding

TDP-43 Loss-of-Function: Biology to BiomarkersP01AG019724 · NIA · UNIVERSITY OF PENNSYLVANIA · PI Jennifer Merrilees · 2002 to 2026
$67.2M
Training - The Frontotemporal Lobar Degeneration Clinical Research ConsortiumU54NS092089 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI BOXER, ADAM L. · 2014 to 2018
$6.4M
Primary Progressive Aphasia: Cognition, Anatomy and ProgressionRF1NS050915 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI GORNO TEMPINI, MARIA LUISA · 2022 to 2022
$4.7M
Training program in the neurology of language and neurodegenerative aphasiasK24DC015544 · NIDCD · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI GORNO TEMPINI, MARIA LUISA · 2016 to 2025
$1.9M
Chinese Language Assessment in Primary Progressive AphasiaR21AG068757 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI GORNO TEMPINI, MARIA LUISA · 2021 to 2022
$360k
NIA NIH HHS P01 AG019724NIA NIH HHS R21 AG068757NIDCD NIH HHS K24 DC015544NINDS NIH HHS RF1 NS050915NINDS NIH HHS U54 NS092089
6 · The paper itself

Abstract

Clinical phenotyping of primary progressive aphasia has largely focused on speech and language presentations, leaving other cognitive domains under-examined. This study investigated the diagnostic utility of visuospatial profiles and examined their neural basis among the three main primary progressive aphasia variants. We studied the neuropsychological performances of 118 primary progressive aphasia participants and 30 cognitively normal controls, across 11 measures of visuospatial cognition, and investigated their neural correlates via voxel-based morphometry analysis using visuospatial composite scores derived from principal component analysis. The principal component analysis identified three main factors: visuospatial-executive, visuospatial-memory and visuomotor components. Logopenic variant primary progressive aphasia performed significantly worst across all components; nonfluent/agrammatic variant primary progressive aphasia showed deficits in the visuospatial-executive and visuomotor components compared with controls; and the semantic variant primary progressive aphasia scored significantly lower than nonfluent/agrammatic variant primary progressive aphasia and control in the visuospatial-memory component. Grey matter volumes over the right parieto-occipital cortices correlated with visuospatial-executive performance; volumetric changes in the right anterior parahippocampal gyrus and amygdala were associated with visuospatial-memory function, and visuomotor composite scores correlated significantly with the grey matter volume at the right precentral gyrus. Discriminant function analysis identified three visuospatial measures: Visual Object and Space Perception and Benson figure copy and recall test, which classified 79.7% (94/118) of primary progressive aphasia into their specific variant. This study shows that each primary progressive aphasia variant also carries a distinctive visuospatial cognitive profile that corresponds with grey matter volumetric changes and in turn can be largely represented by their performance on the visuomotor, visuospatial-memory and executive functions.

Indexed as

primary progressive aphasiavisuospatial

Identifiers

PMID35386217
PMCPMC8977647

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.