ArticleNeurocritical care2022
Sex-Related Differences in Patients' Characteristics, Provided Care, and Outcomes Following Spontaneous Intracerebral Hemorrhage.
Article in Neurocritical care, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it, 26 citations in OpenAlex.
- Influence of gender and sexual hormones on outcomes after pituitary surgery: a systematic review and meta-analysis.Acta neurochirurgica · 2023Pooled it
- Sex Differences in Perihematomal Edema Volume and Outcome After Intracerebral Hemorrhage.Neurocritical care · 2024Trial
- Global Burden of Intracerebral Hemorrhage, 1990-2021, and Projections to 2050: A Global Burden of Disease Study 2021.Journal of Korean medical science · 2026Article
- Non-contrast computed tomography at the end of the acute care phase as an additional prognostic tool after aneurysmal subarachnoid hemorrhage.Neurosurgical review · 2026Article
- Sex-related cardiac complications and their association on functional outcome in patients with aneurysmal subarachnoid hemorrhage: a retrospective study.Neurosurgical review · 2025Article
- Multimodal image fusion-assisted endoscopic evacuation of spontaneous intracerebral hemorrhage.Chinese journal of traumatology = Zhonghua chuang shang za zhi · 2024Article
- Based on hematoma and perihematomal tissue NCCT imaging radiomics predicts early clinical outcome of conservatively treated spontaneous cerebral hemorrhage.Scientific reports · 2024Article
- Cystic vestibular schwannoma - a subgroup analysis from a comparative study between radiosurgery and microsurgery.Neurosurgical review · 2024Article
- Sex differences in the use of mechanical ventilation in a neurointensive care population: a retrospective study.BMC pulmonary medicine · 2024Article
- Sex-Related Differences in Mortality, Delayed Cerebral Ischemia, and Functional Outcomes in Patients with Aneurysmal Subarachnoid Hemorrhage: A Systematic Review and Meta-Analysis.Journal of clinical medicine · 2024Review
- Limitation of life sustaining measures in neurocritical care: sex, timing, and advance directive.Journal of intensive care · 2024Article
- Sex-specific extracerebral complications in patients with aneurysmal subarachnoid hemorrhage.Frontiers in neurology · 2023Article
- Article
- Sex-related differences of invasive therapy in patients with aneurysmal subarachnoid hemorrhage.Acta neurochirurgica · 2022Article
- Sex-specific difference in treatment success/failure after vestibular schwannoma treatment.Neuro-oncology advancesArticle
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSex-related differences in patients with spontaneous, non-traumatic intracerebral hemorrhage (ICH) are poorly investigated so far. This study elucidates whether sex-related differences in ICH care in a neurocritical care setting exist, particularly regarding provided care, while also taking patient characteristics, and outcomes into account.
methodsThis retrospective single center study includes all consecutive patients with spontaneous ICH admitted to the neurocritical care unit in a 10-year period. Patients' demographics, comorbidities, symptoms at presentation, radiological findings, surgical and medical provided care, intensive care unit mortality and 12 month-mortality, and functional outcome at discharge were compared among men and women.
resultsOverall, 398 patients were included (male = 198 and female = 200). No differences in demographics, Charlson Comorbidity Index (CCI), symptoms at presentation, radiological findings, intensive care unit mortality and 12-month mortality were observed among men and women. Men received an external ventricular drain (EVD) for hydrocephalus-therapy significantly more often than women, despite similar location of the ICH and radiographic parameters. In the multivariate analysis, EVD insertion was independently associated with male sex (odds ratio 2.82, 95% confidence interval 1.61-4.95, P < 0.001) irrespective of demographic or radiological features. Functional outcome after ICH as assessed by the modified Rankin scale, was more favorable for women (P = 0.044).
conclusionsSex-related differences in patients with ICH regarding to provided neurosurgical care exist. We provide evidence that insertion of EVD is associated with male sex, disregarding clear reasoning. A sex-bias as well as social factors may play a significant role in decision-making for the insertion of an EVD.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.