SynthesisPlanta2022
A systems biology study unveils the association between a melatonin biosynthesis gene, O-methyl transferase 1 (OMT1) and wheat (Triticum aestivum L.) combined drought and salinity stress tolerance.
Synthesis in Planta, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it, 27 citations in OpenAlex.
- A meta-analysis of photosynthetic efficiency and stress mitigation by melatonin in enhancing wheat tolerance.BMC plant biology · 2024Pooled it
- Integrative multi-scale analysis reveals a candidate melatonin receptor associated with early salinity response networks in barley.Scientific reports · 2026Article
- From Model Plants to Staple Crops: Molecular Mechanisms of Plant Saline-Alkali Tolerance.Plants (Basel, Switzerland) · 2026Review
- The regulatory roles of flavonoids, melatonin, and glycine betaine in plant salt stress response.Frontiers in plant science · 2026Review
- Stable genetic loci orchestrate redox networks and grain traits in polyploid wheat (Triticum aestivum L.) under combined salinity and drought stress.Molecular genetics and genomics : MGG · 2025Article
- The CGA1-SNAT regulatory module potentially contributes to cytokinin-mediated melatonin biosynthesis and drought tolerance in wheat.BMC plant biology · 2025Article
- Identification of Ethylene Response Factors in Wheat Reveals ThatPlants (Basel, Switzerland) · 2025Article
- Integrated agronomy of pea (Frontiers in plant science · 2025Review
- Enhancing drought stress tolerance in horticultural plants through melatonin-mediated phytohormonal crosstalk.Plant cell reports · 2024Review
- Response of winter wheat genotypes to salinity stress under controlled environments.Frontiers in plant science · 2024Article
- Potential role of the regulatoryFrontiers in plant science · 2023Article
- Crosstalk between Melatonin and Reactive Oxygen Species in Plant Abiotic Stress Responses: An Update.International journal of molecular sciences · 2022Review
- Integrative Multi-Scale Analysis Identifies the Hub Gene TRE1 Associating Trehalose Metabolism With Salinity Tolerance in Rice.Physiologia plantarumArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
MAIN
conclusionEnhanced levels of endogenous melatonin in the root of wheat, mainly through the OMT1 gene, augment the antioxidant system, reestablish redox homeostasis and are associated with combined stress tolerance. A systems biology approach, including a collection of computational analyses and experimental assays, led us to uncover some aspects of a poorly understood phenomenon, namely wheat (Triticum aestivum L.) combined drought and salinity stress tolerance. Accordingly, a cross-study comparison of stress experiments was performed via a meta-analysis of Expressed Sequence Tags (ESTs) data from wheat roots to uncover the overlapping gene network of drought and salinity stresses. Identified differentially expressed genes were functionally annotated by gene ontology enrichment analysis and gene network analysis. Among those genes, O-methyl transferase 1 (OMT1) was highlighted as a more important (hub) gene in the dual-stress response gene network. Afterwards, the potential roles of OMT1 in mediating physiochemical indicators of stress tolerance were investigated in two wheat genotypes differing in abiotic stress tolerance. Regression analysis and correspondence analysis (CA) confirmed that the expression profiles of the OMT1 gene and variations in melatonin content, antioxidant enzyme activities, proline accumulation, H
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.