ArticleJournal of Yeungnam medical science2022
The mechanism of action of pulsed radiofrequency in reducing pain: a narrative review.
Article in Journal of Yeungnam medical science, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 46 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Predictors of Treatment Response to Greater Occipital Nerve Pulsed Radiofrequency in Older Patients With Chronic Migraine
Ultrasound-Guided Pulsed Radiofrequency Neuromodulation Versus Ultrasound -Guided Phenol Neurolysis in Post-Stroke Hemiplegic Shoulder Pain: A Randomized Controlled Trial
Who cites it
46 citing papers in PubMed.
- Effects of DRG pulsed radiofrequency parameters on the clinical outcome for battered sensory never syndrome: a prospective, triple-blind, randomized controlled trial.Scientific reports · 2026Trial
- Comparing Ultrasound-Guided Injection of Oxygen-Ozone vs. Corticosteroid vs. Prolotherapy in the Treatment of Shoulder Tendinopathy: A Prospective, Multicenter Randomized Clinical Trial.Pain research & management · 2026Trial
- Efficacy of semilunar ganglion radiofrequency thermal coagulation in moderate and severe trigeminal postherpetic neuralgia and its impact on serum IL-1β and IL-6 levels.European journal of medical research · 2025Trial
- Effectiveness of distal versus proximal greater occipital nerve pulsed radiofrequency in migraine management: a prospective randomized controlled trial.Turkish journal of medical sciences · 2025Trial
- Effectiveness of combining greater occipital nerve block and pulsed radiofrequency treatment in patients with chronic migraine: a double-blind, randomized controlled trial.Head & face medicine · 2024Trial
- Comparison of two distinct needle tip positions in pulsed radiofrequency for herpes zoster-related pain.CNS neuroscience & therapeutics · 2023Trial
- Comparison of Pain and Quality-of-Life Outcomes Following Bipolar Versus Monopolar Pulsed Radiofrequency Treatment for Chronic Lumbosacral Radicular Pain: An Observational Study.Pain practice : the official journal of World Institute of Pain · 2026Observational
- Intra-Articular Steroid Injection with or Without Pulsed Radiofrequency in Knee Osteoarthritis: A Retrospective Comparative Study.Medicina (Kaunas, Lithuania) · 2026Article
- Research Progress on Low-Temperature Plasma Nucleoplasty and Targeted Radiofrequency for Cervical Spondylotic Radiculopathy: A Retrospective Review.Pain and therapy · 2026Review
- Transcutaneous Pulsed Radiofrequency in Chronic Pain: A Systematic Review of Randomized Controlled Trials.Pain and therapy · 2026Review
- Fluoroscopy- and Ultrasound-Guided Intra-Articular Pulsed Radiofrequency of the Atlanto-Occipital Joint for Chronic Post-Traumatic Neck Pain: A Retrospective Preliminary Case Series.Journal of clinical medicine · 2026Article
- Article
- [Comparison of the clinical efficacy of continuous radiofrequency and pulsed radiofrequency in the treatment of elderly patients with thoracic postherpetic neuralgia].Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences · 2026Article
- Peripheral Neuropathy: A Phenotype-Driven Review for Diagnosis and Management.Revista de neurologia · 2026Review
- Pulsed radiofrequency of S2-4 nerve roots vs ganglion impar neurolysis for severe perineal cancer pain.Pain reports · 2026Article
- Article
- Pulsed radiofrequency therapy ameliorates steroid-induced osteonecrosis of the femoral head by promoting nerve growth factor production.Cytotechnology · 2026Article
- Dorsal root ganglion neuromodulation restores accumbal gate to inhibit mechanical allodynia.The journal of headache and pain · 2026Article
- Duration Dependent Outcomes of Combined Dorsal Root Ganglion Pulsed Radiofrequency and Epidural Steroid Injection in Chronic Lumbosacral Radicular Pain.Journal of clinical medicine · 2026Article
- Comparative Efficacy of Pulsed Radiofrequency-Based and Related Interventions for Postherpetic Neuralgia: A Network Meta-Analysis of Randomized Controlled Trials.Journal of pain research · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Pain from nervous or musculoskeletal disorders is one of the most common complaints in clinical practice. Corticosteroids have a high pain-reducing effect, and their injection is generally used to control various types of pain. However, they have various adverse effects including flushing, hyperglycemia, allergic reactions, menstrual changes, immunosuppression, and adrenal suppression. Pulsed radiofrequency (PRF) is known to have a pain-reducing effect similar to that of corticosteroid injection, with nearly no major side effects. Therefore, it has been widely used to treat various types of pain, such as neuropathic, joint, discogenic, and muscle pain. In the current review, we outlined the pain-reducing mechanisms of PRF by reviewing previous studies. When PRF was first introduced, it was supposed to reduce pain by long-term depression of pain signaling from the peripheral nerve to the central nervous system. In addition, deactivation of microglia at the level of the spinal dorsal horn, reduction of proinflammatory cytokines, increased endogenous opioid precursor messenger ribonucleic acid, enhancement of noradrenergic and serotonergic descending pain inhibitory pathways, suppression of excitation of C-afferent fibers, and microscopic damage of nociceptive C- and A-delta fibers have been found to contribute to pain reduction after PRF application. However, the pain-reducing mechanism of PRF has not been clearly and definitely elucidated. Further studies are warranted to clarify the pain-reducing mechanism of PRF.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.