ArticleBritish journal of haematology2022
The Montreal cognitive assessment as a cognitive screening tool in sickle cell disease: Associations with clinically significant cognitive domains.
Article in British journal of haematology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 16 citations in OpenAlex.
- Stroke burden and functional impacts in adults with sickle cell disease.British journal of haematology · 2026Article
- Electrophysiological and Psychological Correlates of Cognition in Adult Homozygous Sickle Cell Disease Patients.Annals of neurosciences · 2026Article
- Academic Proficiency in Ugandan Children With Sickle Cell Anemia: A Cross-Sectional Study.Pediatric blood & cancer · 2025Article
- Neurological management of ischemic stroke in sickle cell disease- a case report with an updated review of the literature.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2025Review
- Late effects of hemopoietic stem cell transplant for sickle cell disease: monitoring and management.Expert review of hematology · 2024Review
- Article
- Health literacy correlates with abbreviated full-scale IQ in adolescent and young adults with sickle cell disease.Pediatric blood & cancer · 2023Article
- Early Strokes Are Associated with More Global Cognitive Deficits in Adults with Sickle Cell Disease.Journal of clinical medicine · 2023Article
- Assessment of transition readiness to predict health care utilization during transition to adult care in sickle cell disease.Expert review of hematology · 2022Article
- Regression-Based Normative Data for the Montreal Cognitive Assessment (MoCA) and Its Memory Index Score (MoCA-MIS) for Individuals Aged 18-91.Journal of clinical medicine · 2022Article
- The Montreal cognitive assessment as a cognitive screening tool in sickle cell disease: Associations with clinically significant cognitive domains.British journal of haematology · 2022Article
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Authors and funding
8 authors at 6 institutions in 1 country.
Funding
Abstract
Adults with sickle cell disease (SCD) are at risk for cognitive impairment, which causes significant morbidity. Guidelines support routine cognitive screening, but no screening test is validated in this population. We explored the Montreal Cognitive Assessment (MoCA) as a possible screening test in SCD. We administered the MoCA; a literacy test, the Wide Range Achievement Test, fourth edition (WRAT-4); and a health literacy test, the Shortened Test of Functional Health Literacy in Adults (S-TOFHLA) to adults with SCD and gathered clinical variables through chart review. Spearman's rho, Mann-Whitney, and Kruskal-Wallis tests and quantile regression models were used. Among our sample of 49 adults with SCD, the median MoCA score was 25.0 [interquartile range (IQR) 22.0-28.0]. Higher educational attainment was associated with MoCA scores (p = 0.001). In multivariable models, MoCA scores were associated with S-TOFHLA (p = 0.001) and WRAT-4 Reading (p = 0.002) scores, and overt stroke (p = 0.03) at the median. This pilot study adds to the limited literature of cognitive screening tests in adults with SCD and demonstrates a relationship between MoCA scores and measures of literacy and health literacy. The MoCA is a promising option for briefly screening for cognitive impairment in adults with SCD, though further study is needed to confirm its validity.
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Registered trials
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