Evidence map›Paper›PMID 35385878›Full record

ArticleTransactions of the Royal Society of Tropical Medicine and Hygiene2022

Detection and significance of neuronal autoantibodies in patients with meningoencephalitis in Vientiane, Lao PDR.

Christopher E Uy, Mayfong Mayxay, Ruby Harrison, Adam Al-Diwani, Leslie Jacobson, Sayaphet Rattanavong, Audrey Dubot-Pérès, Manivanh Vongsouvath, Viengmon Davong, Vilada Chansamouth and 4 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Transactions of the Royal Society of Tropical Medicine and Hygiene, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.5field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. In Children,Open forum infectious diseases · 2024
    Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 5 institutions in 5 countries.

Christopher E UyOxford Autoimmune Neurology Group, Nuffield Department of Clinical Neurosciences, Nuffield Department of Medicine, Oxford University, John Radcliffe Hospital, Oxford OX3 9DU, UK.
Mayfong MayxayLao-Oxford-Mahosot Hospital-Wellcome Research Unit OX3 7JX (LOMWRU), Microbiology Laboratory, Mahosot Hospital, Vientiane, Lao PDR.
Ruby HarrisonOxford Autoimmune Neurology Group, Nuffield Department of Clinical Neurosciences, Nuffield Department of Medicine, Oxford University, John Radcliffe Hospital, Oxford OX3 9DU, UK.
Adam Al-DiwaniOxford Autoimmune Neurology Group, Nuffield Department of Clinical Neurosciences, Nuffield Department of Medicine, Oxford University, John Radcliffe Hospital, Oxford OX3 9DU, UK.
Leslie JacobsonOxford Autoimmune Neurology Group, Nuffield Department of Clinical Neurosciences, Nuffield Department of Medicine, Oxford University, John Radcliffe Hospital, Oxford OX3 9DU, UK.
Sayaphet RattanavongLao-Oxford-Mahosot Hospital-Wellcome Research Unit OX3 7JX (LOMWRU), Microbiology Laboratory, Mahosot Hospital, Vientiane, Lao PDR.
Audrey Dubot-PérèsLao-Oxford-Mahosot Hospital-Wellcome Research Unit OX3 7JX (LOMWRU), Microbiology Laboratory, Mahosot Hospital, Vientiane, Lao PDR.
Manivanh VongsouvathLao-Oxford-Mahosot Hospital-Wellcome Research Unit OX3 7JX (LOMWRU), Microbiology Laboratory, Mahosot Hospital, Vientiane, Lao PDR.
Viengmon DavongLao-Oxford-Mahosot Hospital-Wellcome Research Unit OX3 7JX (LOMWRU), Microbiology Laboratory, Mahosot Hospital, Vientiane, Lao PDR.
Vilada ChansamouthLao-Oxford-Mahosot Hospital-Wellcome Research Unit OX3 7JX (LOMWRU), Microbiology Laboratory, Mahosot Hospital, Vientiane, Lao PDR.
Koukeo PhommasoneLao-Oxford-Mahosot Hospital-Wellcome Research Unit OX3 7JX (LOMWRU), Microbiology Laboratory, Mahosot Hospital, Vientiane, Lao PDR.
Patrick WatersOxford Autoimmune Neurology Group, Nuffield Department of Clinical Neurosciences, Nuffield Department of Medicine, Oxford University, John Radcliffe Hospital, Oxford OX3 9DU, UK.
Sarosh R IraniOxford Autoimmune Neurology Group, Nuffield Department of Clinical Neurosciences, Nuffield Department of Medicine, Oxford University, John Radcliffe Hospital, Oxford OX3 9DU, UK.
Paul N NewtonLao-Oxford-Mahosot Hospital-Wellcome Research Unit OX3 7JX (LOMWRU), Microbiology Laboratory, Mahosot Hospital, Vientiane, Lao PDR.
Lao-Oxford-Mahosot Hospital-Wellcome Trust Research Unit · LAMahosot Hospital · LAUniversity of Oxford · GBJohn Radcliffe Hospital · GBUniversity of British Columbia Hospital · CA

Funding

Department of HealthMedical Research Council MR/V007173/1Wellcome TrustWellcome Trust 104079/Z/14/ZWellcome Trust 205126/Z/16/Z
6 · The paper itself

Abstract

backgroundThe importance of autoimmune encephalitis and its overlap with infectious encephalitides are not well investigated in South-East Asia.

methodsWe report autoantibody testing, using antigen-specific live cell-based assays, in a series of 134 patients (cerebrospinal fluid and sera) and 55 blood donor controls (sera), undergoing lumbar puncture for suspected meningoencephalitis admitted in Vientiane, Lao People's Democratic Republic (PDR).

resultsEight of 134 (6%) patients showed detectable serum neuronal autoantibodies, against the N-methyl-D-aspartate and gamma-aminobutyric acid A receptors (NMDAR and GABAAR), and contactin-associated protein-like 2 (CASPR2). Three of eight patients had accompanying autoantibodies in cerebrospinal fluid (two with NMDAR and one with GABAAR antibodies), and in two of these the clinical syndromes were typical of autoimmune encephalitis. Three of the other five patients had proven central nervous system infections, highlighting a complex overlap between diverse infectious and autoimmune causes of encephalitis. No patients in this cohort were treated with immunotherapy, and the outcomes were poor, with improvement observed in a single patient.

conclusionsIn Lao PDR, autoimmune encephalitis is underdiagnosed and has a poor prognosis. Empiric immunotherapy should be considered after treatable infectious aetiologies are considered unlikely. Awareness and diagnostic testing resources for autoimmune encephalitis should be enhanced in South-East Asia.

Indexed as

EncephalitisMeningoencephalitisAutoantibodiesContactinsgamma-Aminobutyric AcidHashimoto DiseaseHumansLaosN-MethylaspartateReceptors, GABA-AReceptors, N-Methyl-D-AspartateAutoantibodiesContactinsgamma-Aminobutyric AcidN-MethylaspartateReceptors, GABA-AReceptors, N-Methyl-D-AspartateautoimmuneLaosLGI1meningoencephalitisneuroimmunologyNMDAR

Identifiers

PMID35385878
PMCPMC9526827
OpenAlexW4225673917

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.