ArticleNature2022
FcγR-mediated SARS-CoV-2 infection of monocytes activates inflammation.
Open access · bronzeAbstract read
In one paragraph
Article in Nature, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 393 papers, 2 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
393citing papers in PubMed, 2 pooled it
55.9field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
393 citing papers in PubMed, 2 syntheses or guidelines pooled it, 565 citations in OpenAlex.
- Peripheral immune progression to long COVID is associated with mitochondrial gene transcription: A meta-analysis.Mitochondrion · 2025Pooled it
- Mucosal immune response in biology, disease prevention and treatment.Signal transduction and targeted therapy · 2025Pooled it
- Gapmers targeting conserved SARS-CoV-2 single-stranded regions reduce viral load and reshape inflammatory macrophage responses.iScience · 2026Article
- Inflammasomes in respiratory diseases: from disease pathogenesis to drug development and use of multi-omics.European respiratory review : an official journal of the European Respiratory Society · 2026Review
- Beyond correlation and causation: epistemic caution, anomalous findings, and COVID-19 vaccine safety.Philosophy, ethics, and humanities in medicine : PEHM · 2026Review
- Caspase-11-mediated hyperinflammation impairs CD8+ T cell immunity and viral clearance in severe SARS-CoV-2 infection.JCI insight · 2026Article
- Secreted ORF8 reprograms macrophages to enhance SARS-CoV-2 infection of lung epithelial cells.Science advances · 2026Article
- Mechanisms of antibody-dependent enhancement and its research progress in animal coronaviruses.Veterinary research · 2026Review
- Let-7a-5p/SHIP-1 Axis Drives SARS-CoV-2 Spike-1-Induced Microglial Pyroptosis.International journal of molecular sciences · 2026Article
- Mechanisms and therapeutic strategies of pyroptosis in sepsis‑induced acute lung injury (Review).International journal of molecular medicine · 2026Review
- Vaccination-first immune priming shapes a sustained mRNA vaccine-induced IgG4 class switch that associates with SARS-CoV-2 breakthrough infection risk.Scientific reports · 2026Article
- Longitudinal analysis reveals myeloid cell contributions to murine neuroPASC pathogenesis.Nature communications · 2026Article
- Targeting the NLRP3 Inflammasome with Colchicine in COVID-19: Therapeutic Evidence and Future Implications for Influenza.International journal of molecular sciences · 2026Review
- The cell with many faces: lung macrophage plasticity and function in response to environmental and pathogenic insults.Physiological reviews · 2026Review
- Clinical Manifestations and Immunological Impacts in Co-Infections and Sequential Infections of SARS-CoV-2 and Arboviruses.Current microbiology · 2026Review
- Efferocytosis of apoptotic bodies drives SARS-CoV-2 infection and macrophage inflammation.Nature communications · 2026Article
- Secreted ORF8 reprograms macrophages to enhance SARS-CoV-2 infection of lung epithelial cells.bioRxiv : the preprint server for biology · 2026Article
- DAMP Laden Extracellular Vesicles From the Airways of Patients With Severe SARS-CoV-2 Respiratory Infection Compromise Inflammation and Cellular Metabolism.Journal of extracellular vesicles · 2026Article
- Modulation of Host Innate Immune Response by Highly Pathogenic Human Coronaviruses during Viral Infection.Journal of microbiology and biotechnology · 2026Review
- Mast cells support lung eosinophil homeostasis and the acute innate immune response to respiratory syncytial virus.Nature communications · 2026Article
333 more citing papers are in PubMed but not listed here.
Corrections and comments
- Commented on by
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Authors and funding
32 authors at 7 institutions in 3 countries.
Caroline Junqueira *Program in Cellular and Molecular Medicine, Boston Children's Hospital, Boston, MA, USA. caroline.junqueira@childrens.harvard.edu.ORCID http://orcid.org/0000-0003-0545-0986
Ângela Crespo *Program in Cellular and Molecular Medicine, Boston Children's Hospital, Boston, MA, USA.
Shahin Ranjbar *Program in Cellular and Molecular Medicine, Boston Children's Hospital, Boston, MA, USA.
Luna B de LacerdaProgram in Cellular and Molecular Medicine, Boston Children's Hospital, Boston, MA, USA.
Mercedes LewandrowskiProgram in Cellular and Molecular Medicine, Boston Children's Hospital, Boston, MA, USA.ORCID http://orcid.org/0000-0003-2613-8860
Jacob IngberProgram in Cellular and Molecular Medicine, Boston Children's Hospital, Boston, MA, USA.ORCID http://orcid.org/0000-0001-8820-5024
Blair ParryEmergency Medicine, Institute for Patient Care, Massachusetts General Hospital, Boston, MA, USA.ORCID http://orcid.org/0000-0002-6230-5286
Sagi RavidProgram in Cellular and Molecular Medicine, Boston Children's Hospital, Boston, MA, USA.ORCID http://orcid.org/0000-0003-4292-2305
Sarah ClarkDepartment of Microbiology, Blavatnik Institute, Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0001-9944-0919
Marie Rose SchrimpfProgram in Cellular and Molecular Medicine, Boston Children's Hospital, Boston, MA, USA.
Felicia HoProgram in Cellular and Molecular Medicine, Boston Children's Hospital, Boston, MA, USA.
Caroline BeakesEmergency Medicine, Institute for Patient Care, Massachusetts General Hospital, Boston, MA, USA.ORCID http://orcid.org/0000-0003-1141-392X
Justin MargolinEmergency Medicine, Institute for Patient Care, Massachusetts General Hospital, Boston, MA, USA.ORCID http://orcid.org/0000-0001-5544-7318
Nicole RussellEmergency Medicine, Institute for Patient Care, Massachusetts General Hospital, Boston, MA, USA.
Kyle KaysEmergency Medicine, Institute for Patient Care, Massachusetts General Hospital, Boston, MA, USA.
Julie BoucauRagon Institute, Massachusetts General Hospital, Massachusetts Institute of Technology, Harvard Medical School, Cambridge, MA, USA.
Upasana Das AdhikariRagon Institute, Massachusetts General Hospital, Massachusetts Institute of Technology, Harvard Medical School, Cambridge, MA, USA.
Setu M VoraProgram in Cellular and Molecular Medicine, Boston Children's Hospital, Boston, MA, USA.
Valerie LegerInstitute for Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge, MA, USA.
Lee GehrkeDepartment of Microbiology, Blavatnik Institute, Harvard Medical School, Boston, MA, USA.
Lauren A HendersonDepartment of Pediatrics, Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0003-0242-4029
Erin JanssenDepartment of Pediatrics, Harvard Medical School, Boston, MA, USA.
Douglas KwonRagon Institute, Massachusetts General Hospital, Massachusetts Institute of Technology, Harvard Medical School, Cambridge, MA, USA.ORCID http://orcid.org/0000-0001-8521-8735
Chris SandercBio Center, Dana-Farber Cancer Institute and Department of Cell Biology, Harvard Medical School, Boston, MA, USA.
Jonathan AbrahamDepartment of Microbiology, Blavatnik Institute, Harvard Medical School, Boston, MA, USA.
Marcia B GoldbergDepartment of Microbiology, Blavatnik Institute, Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0003-4266-9733
Hao WuProgram in Cellular and Molecular Medicine, Boston Children's Hospital, Boston, MA, USA.ORCID http://orcid.org/0000-0002-7281-8579
Gautam MehtaInstitute for Liver and Digestive Health, University College London, London, UK.ORCID http://orcid.org/0000-0002-5696-359X
Steven BellDepartment of Clinical Neurosciences, University of Cambridge, Cambridge, UK.ORCID http://orcid.org/0000-0001-6774-3149
Anne E GoldfeldProgram in Cellular and Molecular Medicine, Boston Children's Hospital, Boston, MA, USA.
Michael R FilbinEmergency Medicine, Institute for Patient Care, Massachusetts General Hospital, Boston, MA, USA. mfilbin@mgh.harvard.edu.ORCID http://orcid.org/0000-0002-2588-7504
Judy LiebermanProgram in Cellular and Molecular Medicine, Boston Children's Hospital, Boston, MA, USA. judy.lieberman@childrens.harvard.edu.ORCID http://orcid.org/0000-0002-6200-4715
Boston Children's Hospital · USHarvard University · USMassachusetts General Hospital · USFoundation for Liver Research · GBMassachusetts Institute of Technology · USMGH Institute of Health Professions · USUniversity of Cambridge · GB
Funding
VectorP30CA006516 · NCI · DANA-FARBER CANCER INSTITUTE · PI A. Heather Eliassen · 1985 to 2026
$330.6MThe impact of HIV viral diversity and cellular immunity on HIV pathogenesisP30AI060354 · NIAID · HARVARD UNIVERSITY (MEDICAL SCHOOL) · PI ROBERT A. PARKER · 2004 to 2026
$94.4MMOLECULAR BASIS OF VIRAL INFECTIVITYT32AI007245 · NIAID · HARVARD UNIVERSITY (MEDICAL SCHOOL) · PI Aaron Gregory Schmidt · 1985 to 2026
$11.3MVirology Core: MIT Center for Human Tissue Models for Infectious Diseases (MIT.HTMID)U19AI131135 · NIAID · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI GEHRKE, LEE · 2017 to 2021
$8.7MNLRP1 and CARD8 Inflammasomes: Assembly, Regulation and Stress SensingR01AI124491 · NIAID · BOSTON CHILDREN'S HOSPITAL · PI WU, HAO · 2016 to 2025
$5.1MBritish Heart FoundationNCI NIH HHS P30 CA006516NIAID NIH HHS P30 AI060354NIAID NIH HHS R01 AI124491NIAID NIH HHS T32 AI007245NIAID NIH HHS U19 AI131135
Abstract
SARS-CoV-2 can cause acute respiratory distress and death in some patients
Indexed as
COVID-19InflammationMonocytesReceptors, IgGSARS-CoV-2Caspase 1DNA-Binding ProteinsGasderminsHumansInflammasomesNLR Family, Pyrin Domain-Containing 3 ProteinPhosphate-Binding ProteinsPore Forming Cytotoxic ProteinsAIM2 protein, humanCaspase 1DNA-Binding ProteinsGasderminsGSDMD protein, humanInflammasomesNLR Family, Pyrin Domain-Containing 3 ProteinNLRP3 protein, humanPhosphate-Binding ProteinsPore Forming Cytotoxic ProteinsReceptors, IgG
Identifiers
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.