ArticleCell reports2022
Affinity requirements for control of synaptic targeting and neuronal cell survival by heterophilic IgSF cell adhesion molecules.
Article in Cell reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 24 citations in OpenAlex.
- The neurotrophin DNT-2 via the Toll-2 receptor regulates neuronal survival and morphology during visual system development.Biology open · 2026Article
- Beat- and Side-family cell-surface molecules are expressed combinatorially in the partner neurons of the olfactory circuit in Drosophila.PLoS biology · 2026Article
- Structure of the Beat-Side complex reveals their interaction is required for neuromuscular system wiring.Cell reports · 2026Article
- Formation of sensory maps: New tools reveal novel insights into neural development.Current opinion in neurobiology · 2025Review
- A critical affinity window for IgSF proteins DIP-α and Dpr10 is required for proper motor neuron arborization.Genes & development · 2025Article
- FETCH enables fluorescent labeling of membrane proteins in vivo with spatiotemporal control inProceedings of the National Academy of Sciences of the United States of America · 2025Article
- Structural insights into wiring specificity in the neuromuscular system through the Beat-Side complex.bioRxiv : the preprint server for biology · 2025Article
- Members of the DIP and Dpr adhesion protein families use cis inhibition to shape neural development in Drosophila.PLoS biology · 2025Article
- Functional insights into immunoglobulin superfamily proteins in invertebrate neurobiology and immunity.Frontiers in immunology · 2025Review
- Molecular and Cellular Mechanisms of Motor Circuit Development.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Review
- Resolving candidate genes of duck ovarian tissue transplantation via RNA-Seq and expression network analyses.Poultry science · 2024Article
- hkb is required for DIP-α expression and target recognition in the Drosophila neuromuscular circuit.Communications biology · 2024Article
- Article
- Biased cell adhesion organizes a circuit for visual motion integration.bioRxiv : the preprint server for biology · 2023Article
- Article
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Authors and funding
10 authors at 4 institutions in 1 country.
Funding
Abstract
Neurons in the developing brain express many different cell adhesion molecules (CAMs) on their surfaces. CAM-binding affinities can vary by more than 200-fold, but the significance of these variations is unknown. Interactions between the immunoglobulin superfamily CAM DIP-α and its binding partners, Dpr10 and Dpr6, control synaptic targeting and survival of Drosophila optic lobe neurons. We design mutations that systematically change interaction affinity and analyze function in vivo. Reducing affinity causes loss-of-function phenotypes whose severity scales with the magnitude of the change. Synaptic targeting is more sensitive to affinity reduction than is cell survival. Increasing affinity rescues neurons that would normally be culled by apoptosis. By manipulating CAM expression together with affinity, we show that the key parameter controlling circuit assembly is surface avidity, which is the strength of adherence between cell surfaces. We conclude that CAM binding affinities and expression levels are finely tuned for function during development.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.