Evidence map›Paper›PMID 35385692›Full record

ArticleCurrent biology : CB2022

Median preoptic GABA and glutamate neurons exert differential control over sleep behavior.

Natalia L S Machado, William D Todd, Satvinder Kaur, Clifford B Saper

Open access · bronzeAbstract read
In one paragraph

Article in Current biology : CB, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
7.2field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 53 citations in OpenAlex.

  1. Pharmaceutical biology · 2026
    Review
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  9. The locus coeruleus maintains core body temperature and protects against hypothermia during dexmedetomidine-induced sedation.Proceedings of the National Academy of Sciences of the United States of America · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Natalia L S MachadoDepartment of Neurology, Beth Israel-Deaconess Medical Center, Harvard Medical School, 330 Brookline Avenue, Boston, MA 02215, USA.
William D ToddDepartment of Neurology, Beth Israel-Deaconess Medical Center, Harvard Medical School, 330 Brookline Avenue, Boston, MA 02215, USA; Department of Zoology and Physiology, Program in Neuroscience, University of Wyoming, Laramie, WY 82071, USA.
Satvinder KaurDepartment of Neurology, Beth Israel-Deaconess Medical Center, Harvard Medical School, 330 Brookline Avenue, Boston, MA 02215, USA.
Clifford B SaperDepartment of Neurology, Beth Israel-Deaconess Medical Center, Harvard Medical School, 330 Brookline Avenue, Boston, MA 02215, USA. Electronic address: csaper@bidmc.harvard.edu.
Beth Israel Deaconess Medical Center · USUniversity of Wyoming · US

Funding

Wakefulness and Forebrain Activation by Orexin NeuronsP01HL095491 · NHLBI · BETH ISRAEL DEACONESS MEDICAL CENTER · PI WELLMAN, DAVID ANDREW · 2010 to 2019
$25.1M
Project 5: Novel strategies to prevent opioid-induced hypoventilation during sleep and identification of underlying mechanismsP01HL149630 · NHLBI · BETH ISRAEL DEACONESS MEDICAL CENTER · PI Roberto De Luca · 2020 to 2026
$22.3M
Circuitry for Circadian RhythmsR01NS072337 · NINDS · BETH ISRAEL DEACONESS MEDICAL CENTER · PI SAPER, CLIFFORD B · 2010 to 2023
$4.8M
Hypothalamic arousal systemsR01NS085477 · NINDS · BETH ISRAEL DEACONESS MEDICAL CENTER · PI SAPER, CLIFFORD B · 2014 to 2018
$2.8M
Dissection of the Circuitry Regulating Arousal to PainR01NS112175 · NINDS · BETH ISRAEL DEACONESS MEDICAL CENTER · PI KAUR, SATVINDER · 2019 to 2023
$1.9M
NHLBI NIH HHS P01 HL095491NHLBI NIH HHS P01 HL149630NINDS NIH HHS R01 NS072337NINDS NIH HHS R01 NS085477NINDS NIH HHS R01 NS112175
6 · The paper itself

Abstract

Previous studies suggest that the median preoptic nucleus (MnPO) of the hypothalamus plays an important role in regulating the wake-sleep cycle and, in particular, homeostatic sleep drive. However, the precise cellular phenotypes, targets, and central mechanisms by which the MnPO neurons regulate the wake-sleep cycle remain unknown. Both excitatory and inhibitory MnPO neurons innervate brain regions implicated in sleep promotion and maintenance, suggesting that both cell types may participate in sleep control. Using genetically targeted approaches, we investigated the role of the MnPO GABAergic (MnPO

Indexed as

Glutamic AcidPreoptic AreaAnimalsgamma-Aminobutyric AcidMiceNeuronsSleepgamma-Aminobutyric AcidGlutamic AcidGABAergic neuronsglutamatergic neuronsmedian preoptic nucleussleep homeostasisstress-induced insomnia

Identifiers

PMID35385692
PMCPMC9090993
OpenAlexW4225313395

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.