ArticleCell2022
A male-derived nonribosomal peptide pheromone controls female schistosome development.
Article in Cell, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.
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Who cites it
41 citing papers in PubMed, 75 citations in OpenAlex.
- Article
- An injury-responsivebioRxiv : the preprint server for biology · 2026Article
- G protein-coupled receptor SmGPCR9 interacts with neuropeptides and controls spermatogenesis in Schistosoma mansoni.PLoS pathogens · 2026Article
- Schistosoma japonicum histone acetyltransferase 1 (SjHAT1): A novel anti-schistosomal drug target.PLoS pathogens · 2026Article
- A male-pheromone-elevated transcription factor ZNF362.1 in female schistosomes determines sexual maturation.Science advances · 2026Article
- Dynamic single-cell transcriptomics reveals lsamp-guided neural network formation in male S. japonicum driving female reproduction.Nature communications · 2026Article
- NResearch (Washington, D.C.) · 2026Article
- Loss of vitamin C biosynthesis protects from the pathology of a parasitic infection.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Non-parasite genome encoded virus-like RNAs reprogram the pathogenicity of human blood flukes.Nature communications · 2025Article
- Genome-wide identification and functional characterization of GPCR family genes reveal their key roles in the vitellarium development and egg production in Schistosoma japonicum.Parasites & vectors · 2025Article
- Comparative microRNAs profile of Schistosoma japonicum male worms derived from single-sex and bisexual infections: Implications of the multifunctional role of microRNA.Parasitology research · 2025Article
- A Krüppel-like factor establishes cellular heterogeneity during schistosome tegumental maintenance.PLoS pathogens · 2025Article
- The retinoic acid family-like nuclear receptor SmRAR identified by single-cell transcriptomics of ovarian cells controls oocyte differentiation in Schistosoma mansoni.Nucleic acids research · 2025Article
- Hepatocyte nuclear factor 4 located in different developmental stages of Schistosoma japonicum and involved in important metabolic pathways.Biomedical journal · 2025Article
- Neuroschistosomiasis presenting as recurrent seizures: A case report.Surgical neurology international · 2025Article
- Commentary: Molecular characterization ofFrontiers in cellular and infection microbiology · 2025Article
- Schistosoma sex-biased microRNAs regulate ovarian development and egg production by targeting Wnt signaling pathway.Communications biology · 2024Article
- Metabolites play an underappreciated role in development.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- A Krüppel-like factor establishes cellular heterogeneity during schistosome tegumental maintenance.bioRxiv : the preprint server for biology · 2024Article
- A niche-derived nonribosomal peptide triggers planarian sexual development.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
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Authors and funding
11 authors at 3 institutions in 2 countries.
Funding
Abstract
Schistosomes cause morbidity and death throughout the developing world due to the massive numbers of eggs female worms deposit into the blood of their host. Studies dating back to the 1920s show that female schistosomes rely on constant physical contact with a male worm both to become and remain sexually mature; however, the molecular details governing this process remain elusive. Here, we uncover a nonribosomal peptide synthetase that is induced in male worms upon pairing with a female and find that it is essential for the ability of male worms to stimulate female development. We demonstrate that this enzyme generates β-alanyl-tryptamine that is released by paired male worms. Furthermore, synthetic β-alanyl-tryptamine can replace male worms to stimulate female sexual development and egg laying. These data reveal that peptide-based pheromone signaling controls female schistosome sexual maturation, suggesting avenues for therapeutic intervention and uncovering a role for nonribosomal peptides as metazoan signaling molecules.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.