ArticlePloS one2022
Comparative analysis of chloroplast genomes reveals phylogenetic relationships and intraspecific variation in the medicinal plant Isodon rubescens.
Article in PloS one, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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21 citing papers in PubMed, 39 citations in OpenAlex.
- The Complete Chloroplast Genome Sequences ofEcology and evolution · 2026Article
- Genomic insights into adaptive divergence and genetic vulnerability to climate change of the medicinal plant Isodon rubescens (Hemsl.) H. Hara in central China.BMC plant biology · 2026Article
- Genome-wide analysis of TPS family reveals kaurene synthase-like genes inFrontiers in plant science · 2026Article
- Plastomic insights into the genetic variation and phylogenetic relationships of Macadamia.Scientific reports · 2025Article
- Phylogenomic Inference Suggests Differential Deep Time Phylogenetic Signals from Nuclear and Organellar Genomes in Gymnosperms.Plants (Basel, Switzerland) · 2025Article
- Reporting complete chloroplast genome of endangered red mulberry, useful for understanding hybridization and phylogenetic relationships.Scientific reports · 2025Article
- The complete chloroplast genome sequence and phylogenetic analysis ofMitochondrial DNA. Part B, Resources · 2025Article
- Phylogenomics analysis of Scutellaria (Lamiaceae) of the world.BMC biology · 2024Article
- Chloroplast and whole-genome sequencing shed light on the evolutionary history and phenotypic diversification of peanuts.Nature genetics · 2024Article
- The newly assembled chloroplast genome of Aeluropus littoralis: molecular feature characterization and phylogenetic analysis with related species.Scientific reports · 2024Article
- High-quality assembly of the T2T genome for Isodon rubescens f. lushanensis reveals genomic structure variations between 2 typical forms of Isodon rubescens.GigaScience · 2024Article
- Comparative analysis of plastid genomes reveals rearrangements, repetitive sequence features, and phylogeny in the Annonaceae.Frontiers in plant science · 2024Article
- The First Complete Chloroplast Genome ofGenes · 2023Article
- Complete Chloroplast Genome Determination ofGenes · 2023Article
- The Complete Chloroplast Genomes ofGenes · 2023Article
- Phylogenomics and plastome evolution ofFrontiers in plant science · 2023Article
- Characterization of the Chloroplast Genome ofGenes · 2022Article
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- Variations in genetic diversity in cultivatedFrontiers in plant science · 2022Article
- Complete chloroplast genome sequences ofFrontiers in plant science · 2022Article
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7 authors at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
Isodon rubescens (Hemsley) H. Hara (Lamiaceae) is a traditional Chinese medicine plant that has been used to treat various human diseases and conditions such as inflammation, respiratory and gastrointestinal bacterial infections, and malignant tumors. However, the contents of the main active components of I. rubescens from different origins differ significantly, which greatly affected its quality. Therefore, a molecular method to identify and classify I. rubescens is needed. Here, we report the DNA sequence of the chloroplast genome of I. rubescens collected from Lushan, Henan province. The genome is 152,642 bp in length and has a conserved structure that includes a pair of IR regions (25,726 bp), a LSC region (83,527 bp) and a SSC region (17,663 bp). The chloroplast genome contains 113 unique genes, four rRNA genes, 30 tRNA genes, and 79 protein-coding genes, 23 of which contain introns. The protein-coding genes account for a total of 24,412 codons, and most of them are A/T biased usage. We identified 32 simple sequence repeats (SSRs) and 48 long repeats. Furthermore, we developed valuable chloroplast molecular resources by comparing chloroplast genomes from three Isodon species, and both mVISTA and DnaSP analyses showed that rps16-trnQ, trnS-trnG, and ndhC-trnM are candidate regions that will allow the identification of intraspecific differences within I. rubescens. Also 14 candidate fragments can be used to identify interspecific differences between species in Isodon. A phylogenetic analysis of the complete chloroplast genomes of 24 species in subfamily Nepetoideae was performed using the maximum likelihood method, and shows that I. rubescens clustered closer to I. serra than I. lophanthoides. Interestingly, our analysis showed that I. rubescens (MW018469.1) from Xianyang, Shaanxi Province (IR-X), is closer to I. serra than to the other two I. rubescens accessions. These results strongly indicate that intraspecific diversity is present in I. rubescens. Therefore, our results provide further insight into the phylogenetic relationships and interspecific diversity of species in the genus Isodon.
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