Evidence map›Paper›PMID 35385475›Full record

ArticlePloS one2022

Is a single dose of commonly used antibiotics effective in preventing maternal infection after cesarean section? A network meta-analysis.

Ye Huang, Xinbo Yin, Xiaokai Wang, Fangyi Zhou, Xiaoxia Cao, Yeqiong Han, Shichang Sun

Open access · goldAbstract readNetwork Meta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Article in PloS one, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.1field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

  1. Review
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  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Ye HuangSchool of Public Health, Shanxi Medical University, Taiyuan, Shanxi, China.
Xinbo YinDepartment of Emergency Medicine, National Clinical Research Center of Geriatric Disorders (Xiangya Hospital), Central South University, Changsha, Hunan, China.
Xiaokai WangDepartment of Emergency Medicine, National Clinical Research Center of Geriatric Disorders (Xiangya Hospital), Central South University, Changsha, Hunan, China.
Fangyi ZhouDepartment of Emergency Medicine, National Clinical Research Center of Geriatric Disorders (Xiangya Hospital), Central South University, Changsha, Hunan, China.
Xiaoxia CaoDepartment of Emergency Medicine, National Clinical Research Center of Geriatric Disorders (Xiangya Hospital), Central South University, Changsha, Hunan, China.
Yeqiong HanDepartment of Emergency Medicine, National Clinical Research Center of Geriatric Disorders (Xiangya Hospital), Central South University, Changsha, Hunan, China.
Shichang SunDepartment of Emergency Medicine, National Clinical Research Center of Geriatric Disorders (Xiangya Hospital), Central South University, Changsha, Hunan, China.ORCID 0000-0002-9667-5795
Central South University · CNShanxi Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveThis study aimed to compare the efficacy of different antibiotic classes and dosages in preventing maternal infection after cesarean delivery.

methodsDatabases were searched for randomized controlled trials (RCTs) published between January 1980 and January 2021 on antibiotic use for the prevention of maternal infection after cesarean delivery. The outcomes were endometritis, febrile morbidity, and wound infection, reported as odds ratios (OR) and surface under the cumulative ranking curve analysis scores.

resultsA total of 31 RCTs met the inclusion criteria. In the network meta-analysis (NMA) for endometritis, pooled network OR values indicated that the following interventions were superior to placebo: cephalosporins (OR: 0.18, 95% credibility interval [CrI]: 0.07-0.45), penicillins (OR: 0.19, 95% CrI: 0.07-0.50), penicillins (multiple doses) (OR: 0.20, 95% CrI: 0.05-0.65), combination therapies (OR: 0.22, 95% CrI: 0.09-0.54), and cephalosporins (multiple doses) (OR: 0.25, 95% CrI: 0.08-0.74). In the NMA for febrile morbidity, placebo was more effective than the other interventions. In the NMA for wound infection, pooled network OR values indicated that the following interventions were superior to placebo: penicillin (OR: 0.14, 95% CrI: 0.05-0.37), cephalosporins (OR: 0.19, 95% CrI: 0.08-0.41), cephalosporins (multiple doses) (OR: 0.20, 95% CrI: 0.06-0.58), combination therapies (OR: 0.29, 95% CrI: 0.13-0.57), macrolides (OR: 0.33, 95% CrI: 0.15-0.74), and penicillins (multiple doses) (OR: 0.40, 95% CrI: 0.17-0.91).

conclusionsCompared with placebo, a single dose of commonly used antibiotics may prevent maternal infection after cesarean delivery. However, the incidence of febrile morbidity was not reduced.

Indexed as

EndometritisWound InfectionAnti-Bacterial AgentsCephalosporinsCesarean SectionFemaleFeverHumansPenicillinsPregnancyAnti-Bacterial AgentsCephalosporinsPenicillins

Identifiers

PMID35385475
PMCPMC8985944
OpenAlexW4226151474

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.