Evidence map›Paper›PMID 35385311›Full record

ArticleScience advances2022

Mendelian randomization supports bidirectional causality between telomere length and clonal hematopoiesis of indeterminate potential.

Tetsushi Nakao, Alexander G Bick, Margaret A Taub, Seyedeh M Zekavat, Md M Uddin, Abhishek Niroula, Cara L Carty, John Lane, Michael C Honigberg, Joshua S Weinstock and 112 more

Open access · goldAbstract read
In one paragraph

Article in Science advances, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 71 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
71citing papers in PubMed, 1 pooled it
9.4field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

71 citing papers in PubMed, 1 synthesis or guideline pooled it, 86 citations in OpenAlex.

  1. Pooled it
  2. How telomere attrition protects against cancer.Nature reviews. Genetics · 2026
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11 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

122 authors at 20 institutions in 8 countries.

Tetsushi NakaoBroad Institute of MIT and Harvard, Cambridge, MA, USA.ORCID 0000-0001-9979-2682
Alexander G BickBroad Institute of MIT and Harvard, Cambridge, MA, USA.ORCID 0000-0001-5824-9595
Margaret A TaubDepartment of Biostatistics, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.
Seyedeh M ZekavatYale University School of Medicine, New Haven, CT, USA.ORCID 0000-0003-4026-8944
Md M UddinBroad Institute of MIT and Harvard, Cambridge, MA, USA.ORCID 0000-0003-1846-0411
Abhishek NiroulaBroad Institute of MIT and Harvard, Cambridge, MA, USA.ORCID 0000-0002-5904-0635
Cara L CartyInitiative for Research and Education to Advance Community Health, Washington State University, Seattle, WA, USA.ORCID 0000-0002-6378-8195
John LaneDepartment of Laboratory Medicine and Pathology, University of Minnesota Medical School, Minneapolis, MN, USA.ORCID 0000-0002-3582-5825
Michael C HonigbergBroad Institute of MIT and Harvard, Cambridge, MA, USA.ORCID 0000-0001-8630-5021
Joshua S WeinstockCenter for Statistical Genetics, Department of Biostatistics, University of Michigan School of Public Health, Ann Arbor, MI, USA.ORCID 0000-0001-7013-1899
Akhil PampanaBroad Institute of MIT and Harvard, Cambridge, MA, USA.ORCID 0000-0002-4167-0540
Christopher J GibsonDepartment of Medicine, Harvard Medical School, Boston, MA, USA.
Gabriel K GriffinBroad Institute of MIT and Harvard, Cambridge, MA, USA.ORCID 0000-0002-4042-6757
Shoa L ClarkeDivision of Cardiovascular Medicine, Department of Medicine, Stanford University School of Medicine, Stanford, CA, USA.ORCID 0000-0002-6592-1172
Romit BhattacharyaCardiovascular Research Center, Massachusetts General Hospital, Boston, MA, USA.ORCID 0000-0002-0782-4753
Themistocles L AssimesDivision of Cardiovascular Medicine, Department of Medicine, Stanford University School of Medicine, Stanford, CA, USA.ORCID 0000-0003-2349-0009
Leslie S EmeryDepartment of Biostatistics, University of Washington, Seattle, WA, USA.ORCID 0000-0002-9070-9886
Adrienne M StilpDepartment of Biostatistics, University of Washington, Seattle, WA, USA.ORCID 0000-0002-3910-0776
Quenna WongDepartment of Biostatistics, University of Washington, Seattle, WA, USA.ORCID 0000-0002-9027-2100
Jai BroomeDepartment of Biostatistics, University of Washington, Seattle, WA, USA.ORCID 0000-0001-7638-0749
Cecelia A LaurieDepartment of Biostatistics, University of Washington, Seattle, WA, USA.
Alyna T KhanDepartment of Biostatistics, University of Washington, Seattle, WA, USA.ORCID 0000-0002-2240-7931
Albert V SmithCenter for Statistical Genetics, Department of Biostatistics, University of Michigan School of Public Health, Ann Arbor, MI, USA.ORCID 0000-0003-1942-5845
Thomas W BlackwellCenter for Statistical Genetics, Department of Biostatistics, University of Michigan School of Public Health, Ann Arbor, MI, USA.
Veryan CoddDepartment of Cardiovascular Sciences, University of Leicester, Leicester, UK.ORCID 0000-0002-9430-8254
Christopher P NelsonDepartment of Cardiovascular Sciences, University of Leicester, Leicester, UK.ORCID 0000-0001-8025-2897
Zachary T YonedaDivision of Cardiology, Vanderbilt University Medical Center, Nashville, TN, USA.ORCID 0000-0002-2055-732X
Juan M PeraltaDepartment of Human Genetics and South Texas Diabetes and Obesity Institute, University of Texas Rio Grande Valley School of Medicine, Brownsville, TX, USA.ORCID 0000-0002-8811-5579
Donald W BowdenDepartment of Biochemistry, Wake Forest School of Medicine, Winston-Salem, NC, USA.
Marguerite R IrvinDepartment of Biostatistics, School of Public Health, University of Alabama, Birmingham, AL, USA.
Meher BoorgulaDivision of Biomedical Informatics and Personalized Medicine and the Colorado Center for Personalized Medicine, School of Medicine, University of Colorado, Aurora, CO, USA.
Wei ZhaoDepartment of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA.
Lisa R YanekGeneSTAR Research Program, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.ORCID 0000-0001-7117-1075
Kerri L WigginsDepartment of Medicine, University of Washington, Seattle, WA, USA.ORCID 0000-0003-2749-1279
James E HixsonHuman Genetics Center, Department of Epidemiology, Human Genetics, and Environmental Sciences, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX, USA.
C Charles GuDivision of Biostatistics, Washington University School of Medicine, St. Louis, MO, USA.ORCID 0000-0002-8527-8145
Gina M PelosoDepartment of Biostatistics, Boston University School of Public Health, Boston, MA, USA.ORCID 0000-0002-5355-8636
Dan M RodenDepartments of Medicine, Pharmacology, and Biomedical Informatics, Vanderbilt University Medical Center, Nashville, TN, USA.ORCID 0000-0002-6302-0389
Muagututi'a S ReupenaMinistry of Health, Government of Samoa, Apia, Samoa.
Chii-Min HwuSection of Endocrinology and Metabolism, Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan.ORCID 0000-0002-8209-9627
Dawn L DeMeoChanning Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA.
Kari E NorthDepartment of Epidemiology, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, NC, USA.ORCID 0000-0002-8903-0366
Shannon KellyVitalant Research Institute, San Francisco, CA, USA.
Solomon K MusaniJackson Heart Study, Department of Medicine, University of Mississippi Medical Center, Jackson, MS, USA.
Joshua C BisCardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA.ORCID 0000-0002-3409-1110
Donald M Lloyd-JonesDivision of Cardiology Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.ORCID 0000-0003-0847-6110
Jill M JohnsenBloodworks Northwest Research Institute, Seattle, WA, USA.ORCID 0000-0002-2279-2550
Michael PreussThe Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.ORCID 0000-0001-5266-8465
Russell P TracyDepartment of Pathology and Laboratory Medicine, Larner College of Medicine, University of Vermont, Burlington, VT, USA.ORCID 0000-0002-0080-2420
Patricia A PeyserDepartment of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA.ORCID 0000-0002-9717-8459
Dandi QiaoChanning Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA.ORCID 0000-0001-9450-205X
Pinkal DesaiDivision of Hematology and Oncology, Weill Cornell Medical College, New York, NY, USA.
Joanne E CurranDepartment of Human Genetics and South Texas Diabetes and Obesity Institute, University of Texas Rio Grande Valley School of Medicine, Brownsville, TX, USA.ORCID 0000-0002-6898-155X
Barry I FreedmanInternal Medicine-Nephrology, Wake Forest School of Medicine, Winston-Salem, NC, USA.ORCID 0000-0003-0275-5530
Hemant K TiwariDepartment of Epidemiology, School of Public Health, University of Alabama, Birmingham, AL, USA.
Sameer ChavanDivision of Biomedical Informatics and Personalized Medicine and the Colorado Center for Personalized Medicine, School of Medicine, University of Colorado, Aurora, CO, USA.ORCID 0000-0002-0220-0845
Jennifer A SmithDepartment of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA.ORCID 0000-0002-3575-5468
Nicholas L SmithDepartment of Epidemiology, University of Washington, Seattle, WA, USA.
Tanika N KellyDepartment of Epidemiology, Tulane University School of Public Health and Tropical Medicine, New Orleans, LA, USA.ORCID 0000-0002-7348-4451
Bertha HidalgoDepartment of Epidemiology, School of Public Health, University of Alabama, Birmingham, AL, USA.ORCID 0000-0002-2556-1969
L Adrienne CupplesDepartment of Biostatistics, Boston University School of Public Health, Boston, MA, USA.
Daniel E WeeksDepartment of Human Genetics and Biostatistics, University of Pittsburgh, Pittsburgh, PA, USA.ORCID 0000-0001-9410-7228
Nicola L HawleyDepartment of Chronic Disease Epidemiology, Yale University, New Haven, CT, USA.ORCID 0000-0002-2601-3454
Ryan L MinsterDepartment of Human Genetics, University of Pittsburgh, Pittsburgh, PA, USA.ORCID 0000-0001-7382-6717
Samoan Obesity, Lifestyle and Genetic Adaptations Study (OLaGA) Group
Ranjan DekaDepartment of Environmental Health, University of Cincinnati, Cincinnati, OH, USA.
Take T NaseriDepartment of Health, American Samoa Government, Pago Pago, American Samoa, USA.
Lisa de las FuentesDivision of Biostatistics, Washington University School of Medicine, St. Louis, MO, USA.ORCID 0000-0002-4689-325X
Laura M RaffieldDepartment of Genetics, University of North Carolina, Chapel Hill, NC, USA.ORCID 0000-0002-7892-193X
Alanna C MorrisonHuman Genetics Center, Department of Epidemiology, Human Genetics, and Environmental Sciences, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX, USA.
Paul S VriesHuman Genetics Center, Department of Epidemiology, Human Genetics, and Environmental Sciences, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX, USA.
Christie M BallantyneDepartment of Medicine, Baylor College of Medicine, Houston, TX, USA.ORCID 0000-0002-6432-1730
Eimear E KennyInstitute for Genomic Health, Icahn School of Medicine at Mount Sinai, New York, NY, USA.ORCID 0000-0001-9198-759X
Stephen S RichCenter for Public Health Genomics, University of Virginia, Charlottesville, VA, USA.ORCID 0000-0003-3872-7793
Eric A WhitselDepartment of Epidemiology, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, NC, USA.ORCID 0000-0003-4843-3641
Michael H ChoChanning Division of Network Medicine and Division of Pulmonary and Critical Care Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA.ORCID 0000-0002-4907-1657
M Benjamin ShoemakerDivision of Cardiology, Vanderbilt University Medical Center, Nashville, TN, USA.
Betty S PaceDivision of Hematology/Oncology, Department of Pediatrics, Augusta University, Augusta, GA, USA.
John BlangeroDepartment of Human Genetics and South Texas Diabetes and Obesity Institute, University of Texas Rio Grande Valley School of Medicine, Brownsville, TX, USA.
Nicholette D PalmerDepartment of Biochemistry, Wake Forest School of Medicine, Winston-Salem, NC, USA.ORCID 0000-0001-8883-2511
Braxton D MitchellDepartment of Medicine, University of Maryland School of Medicine, Baltimore, MD, USA.ORCID 0000-0003-4920-4744
Alan R ShuldinerDivision of Endocrinology, Diabetes and Nutrition, University of Maryland School of Medicine, Baltimore, MD, USA.ORCID 0000-0001-9921-4305
Kathleen C BarnesDivision of Biomedical Informatics and Personalized Medicine and the Colorado Center for Personalized Medicine, School of Medicine, University of Colorado, Aurora, CO, USA.
Susan RedlineDepartment of Medicine, Harvard Medical School, Boston, MA, USA.ORCID 0000-0002-6585-1610
Sharon L R KardiaDepartment of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA.
Gonçalo R AbecasisCenter for Statistical Genetics, Department of Biostatistics, University of Michigan School of Public Health, Ann Arbor, MI, USA.
Lewis C BeckerGeneSTAR Research Program, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Susan R HeckbertDepartment of Epidemiology, University of Washington, Seattle, WA, USA.ORCID 0000-0002-7100-512X
Jiang HeDepartment of Epidemiology, Tulane University School of Public Health and Tropical Medicine, New Orleans, LA, USA.ORCID 0000-0002-8286-9652
Wendy PostDepartment of Medicine, Division of Cardiology, Johns Hopkins University, Baltimore, MD, USA.ORCID 0000-0002-8655-5204
Donna K ArnettDean's Office, College of Public Health, University of Kentucky, Lexington, KY, USA.ORCID 0000-0003-2219-657X
Ramachandran S VasanDepartment of Biostatistics, Boston University School of Public Health, Boston, MA, USA.ORCID 0000-0001-7357-5970
Dawood DarbarDivision of Cardiology, University of Illinois at Chicago, Chicago, IL, USA.
Scott T WeissDepartment of Medicine, Harvard Medical School, Boston, MA, USA.ORCID 0000-0001-7196-303X
Stephen T McGarveyDepartment of Epidemiology and International Health Institute, Brown University School of Public Health, Providence, RI, USA.ORCID 0000-0003-1233-6970
Mariza de AndradeMayo Clinic, Department of Health Sciences Research, Rochester, MN, USA.
Yii-Der Ida ChenThe Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, USA.
Robert C KaplanDepartment of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, NY, USA.
Deborah A MeyersDivision of Genetics, Genomics and Precision Medicine, University of Arizona, Tucson, AZ, USA.
Brian S CusterVitalant Research Institute, San Francisco, CA, USA.ORCID 0000-0001-6251-366X
Adolfo CorreaDepartments of Medicine and Population Health Science, University of Mississippi Medical Center, Jackson, MS, USA.ORCID 0000-0002-9501-600X
Bruce M PsatyCardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA.
Myriam FornageHuman Genetics Center, Department of Epidemiology, Human Genetics, and Environmental Sciences, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX, USA.
JoAnn E MansonDepartment of Medicine, Harvard Medical School, Boston, MA, USA.ORCID 0000-0002-9426-7595
Eric BoerwinkleCenter for Statistical Genetics, Department of Biostatistics, University of Michigan School of Public Health, Ann Arbor, MI, USA.
Barbara A KonkleDepartment of Medicine, University of Washington, Seattle, WA, USA.ORCID 0000-0002-3959-8797
Ruth J F LoosThe Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.ORCID 0000-0002-8532-5087
Jerome I RotterThe Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, USA.ORCID 0000-0001-7191-1723
Edwin K SilvermanChanning Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA.ORCID 0000-0002-3641-3822
Charles KooperbergFred Hutchinson Cancer Research Center, Seattle, WA, USA.ORCID 0000-0002-7986-8560
John DaneshBritish Heart Foundation Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
Nilesh J SamaniDepartment of Cardiovascular Sciences, University of Leicester, Leicester, UK.ORCID 0000-0002-3286-8133
Siddhartha JaiswalDepartment of Pathology, Stanford University, Stanford, CA, USA.ORCID 0000-0002-9597-0477
Peter LibbyDivision of Cardiovascular Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA.ORCID 0000-0002-1502-502X
Patrick T EllinorBroad Institute of MIT and Harvard, Cambridge, MA, USA.ORCID 0000-0002-2067-0533
Nathan PankratzDepartment of Laboratory Medicine and Pathology, University of Minnesota Medical School, Minneapolis, MN, USA.ORCID 0000-0001-5958-693X
Benjamin L EbertBroad Institute of MIT and Harvard, Cambridge, MA, USA.ORCID 0000-0003-0197-5451
Alexander P ReinerFred Hutchinson Cancer Research Center, Seattle, WA, USA.
Rasika A MathiasGeneSTAR Research Program, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.ORCID 0000-0002-2282-9042
Ron DoThe Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.ORCID 0000-0002-3144-3627
NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium
Pradeep NatarajanBroad Institute of MIT and Harvard, Cambridge, MA, USA.ORCID 0000-0001-8402-7435
Broad Institute · USBrigham and Women's Hospital · USUniversity of Washington · USJohns Hopkins University · USUniversity of Michigan · USUniversity of North Carolina at Chapel Hill · USBoston University · USUniversity of Leicester · GBThe University of Texas Rio Grande Valley · USTulane University · USUniversity of Alabama at Birmingham · USUniversity of Maryland, Baltimore · USAlbert Einstein College of Medicine · USAugusta University · USBaylor College of Medicine · USCenter for Personalized Cancer Treatment · NLPacific Research Institute · USThe University of Texas Health Science Center at Houston · USUniversity of Copenhagen · DKUniversity of Pittsburgh · US

Funding

University of Michigan Training Program in Genomic ScienceT32HG000040 · NHGRI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Sebastian Zoellner · 1995 to 2026
$16.4M
Systems Biology of Airway DiseaseP01HL132825 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI DEMEO, DAWN L · 2016 to 2020
$12.6M
North Carolina Translational and Clinical Science Institute (NC TraCS) KL2KL2TR002490 · NCATS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI WEINBERGER, MORRIS · 2018 to 2022
$11.0M
Studies of Rare Genetic Variation in the Isolated Population of SardiniaR01HL117626 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI ABECASIS, GONCALO · 2013 to 2016
$10.5M
Rare variants and NHLBI traits in deeply phenotyped cohortsR01HL120393 · NHLBI · UNIVERSITY OF WASHINGTON · PI PSATY, BRUCE M, RICE, KENNETH M. · 2014 to 2016
$8.9M
Phenotypic and Molecular Signatures for Sleep Apnea and Related MorbiditiesR35HL135818 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI REDLINE, SUSAN S. · 2017 to 2023
$7.2M
Clonal hematopoiesis in the Womens Health Initiative Memory StudyR01HL148565 · NHLBI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI ALEXANDER P REINER, Eric A. Whitsel · 2019 to 2026
$5.9M
Clonal hematopoiesis in humans: determinants of development and progressionR01HL148050 · NHLBI · BAYLOR COLLEGE OF MEDICINE · PI BALLANTYNE, CHRISTIE MITCHELL, NATARAJAN, PRADEEP · 2019 to 2022
$5.9M
Hispanic Latino Lipid ConsortiumR01HL142302 · NHLBI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Jennifer Below, JOSEPH MCCORMICK · 2018 to 2026
$5.8M
Rare variants and NHLBI traits in deeply phenotyped cohortsU01HL120393 · NHLBI · UNIVERSITY OF WASHINGTON · PI PSATY, BRUCE M, RICE, KENNETH M. · 2017 to 2018
$5.6M
Leveraging Family Data to Identify Genetic Variants for Sleep ApneaR01HL113338 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI LIN, XIHONG, REDLINE, SUSAN S. · 2012 to 2016
$4.4M
Whole-genome sequencing analysis of coronary atherosclerosis and related traitsR01HL146860 · NHLBI · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI DE VRIES, PAUL STEFAN · 2020 to 2024
$3.9M
British Heart Foundation CH/12/2/29428British Heart Foundation RG/13/13/30194British Heart Foundation RG/18/13/33946Medical Research Council MC_PC_17228Medical Research Council MC_QA137853Medical Research Council MR/M012816/1NCATS NIH HHS KL2 TR002490NHLBI NIH HHS HHSN268201800001CNHLBI NIH HHS P01 HL132825NHLBI NIH HHS R01 HL046380NHLBI NIH HHS R01 HL113338NHLBI NIH HHS R01 HL117626NHLBI NIH HHS R01 HL120393NHLBI NIH HHS R01 HL134892NHLBI NIH HHS R01 HL142302NHLBI NIH HHS R01 HL146860NHLBI NIH HHS R01 HL148050NHLBI NIH HHS R01 HL148565NHLBI NIH HHS R35 HL135818NHLBI NIH HHS U01 HL120393NIDDK NIH HHS R01 DK107786NIDDK NIH HHS R01 DK110113NIDDK NIH HHS R01 DK124097
6 · The paper itself

Abstract

Human genetic studies support an inverse causal relationship between leukocyte telomere length (LTL) and coronary artery disease (CAD), but directionally mixed effects for LTL and diverse malignancies. Clonal hematopoiesis of indeterminate potential (CHIP), characterized by expansion of hematopoietic cells bearing leukemogenic mutations, predisposes both hematologic malignancy and CAD.

Identifiers

PMID35385311
PMCPMC8986098
OpenAlexW4224239770

What OpenQuestion holds

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Read underepoch 390

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.