Evidence map›Paper›PMID 35385307›Full record

ArticleScience advances2022

Spontaneous evolution of equilibrium morphology in phospholipid-cholesterol monolayers.

Cain Valtierrez-Gaytan, Joseph M Barakat, Mitchell Kohler, Khanh Kieu, Benjamin L Stottrup, Joseph A Zasadzinski

Abstract read
In one paragraph

Article in Science advances, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Article
  2. From relaxation to buckling: A continuum elastic framework connecting surface instabilities of highly compressed lipid thin films.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  3. Article
  4. Article
  5. Evolution of interfacial mechanics of lung surfactant mimics progression of acute respiratory distress syndrome.Proceedings of the National Academy of Sciences of the United States of America · 2023
    Article
  6. Article
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Cain Valtierrez-GaytanDepartment of Chemical Engineering and Materials Science, University of Minnesota, Minneapolis, MN 55455, USA.ORCID 0000-0003-3091-333X
Joseph M BarakatDepartment of Chemical Engineering, University of California, Santa Barbara, Santa Barbara, CA 93106, USA.ORCID 0000-0001-7761-3874
Mitchell KohlerDepartment of Chemical Engineering and Materials Science, University of Minnesota, Minneapolis, MN 55455, USA.ORCID 0000-0002-6278-159X
Khanh KieuDepartment of Chemical Engineering and Materials Science, University of Minnesota, Minneapolis, MN 55455, USA.
Benjamin L StottrupDepartment of Physics, Augsburg University, Minneapolis, MN 55454, USA.ORCID 0000-0001-8274-7324
Joseph A ZasadzinskiDepartment of Chemical Engineering and Materials Science, University of Minnesota, Minneapolis, MN 55455, USA.ORCID 0000-0001-5663-6989

Funding

LIPID AND PROTEIN EFFECTS ON MONOLAYER STABILITYR01HL051177 · NHLBI · UNIVERSITY OF MINNESOTA · PI Joseph Anthony Zasadzinski · 1994 to 2026
$9.5M
Heterogeneous lung surfactant morphologies: effect on alveolar dynamics, and role in promoting acute respiratory distress syndromeR01HL135065 · NHLBI · UNIVERSITY OF CALIFORNIA SANTA BARBARA · PI SQUIRES, TODD MICHAEL · 2017 to 2020
$1.5M
Role of Monolayer Curvature in Lung Surfactant Morphology and MechanicsF32HL156366 · NHLBI · UNIVERSITY OF CALIFORNIA SANTA BARBARA · PI BARAKAT, JOSEPH MICHAEL · 2021 to 2022
$109k
NHLBI NIH HHS F32 HL156366NHLBI NIH HHS R01 HL051177NHLBI NIH HHS R01 HL135065
6 · The paper itself

Abstract

Competition between intradomain electrostatic repulsions and interdomain line tension leads to domain shape transitions in phase-separating lipid monolayers. The question remains if these morphologies are energy minima or are kinetically trapped metastable states. We show the reversible evolution of uniform width stripe domains from polydisperse semicircular domains in monolayers of dipalmitoylphosphatidylcholine (DPPC), hexadecanol (HD) or palmitic acid (PA), and dihydrocholesterol (DChol). The initial semicircular domains grow at a fixed 2:1 DPPC:HD (or PA) stoichiometry, depleting the liquid phase of HD, leaving behind a liquid enriched in DPPC and DChol. At higher surface pressures, the remaining DPPC precipitates onto existing domains, decreasing the ratio of line tension to the square of the dipole density difference, λ/μ

Identifiers

PMID35385307
PMCPMC8986108

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.