Evidence map›Paper›PMID 35385200›Full record

SynthesisJournal of clinical laboratory analysis2022

Neurological manifestations in patients with COVID-19: A systematic review and meta-analysis.

Marzie Mahdizade Ari, Mohamad Hosein Mohamadi, Negar Shadab Mehr, Sajjad Abbasimoghaddam, Amirhosein Shekartabar, Mohsen Heidary, Saeed Khoshnood

Abstract readMeta-AnalysisSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Journal of clinical laboratory analysis, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 3 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Article
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  6. Article
  7. Review
  8. Overview of Long COVID: Navigating the Aftermath.Journal of Brown hospital medicine · 2025
    Review
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Review
  15. Neurological and neuropsychiatric manifestations in hospitalised patients with COVID-19.The South African journal of psychiatry : SAJP : the journal of the Society of Psychiatrists of South Africa · 2023
    Article
  16. Review
  17. Article
  18. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Marzie Mahdizade AriDepartment of Microbiology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran.
Mohamad Hosein MohamadiStudent Research Committee, Sabzevar University of Medical Sciences, Sabzevar, Iran.
Negar Shadab MehrStudent Research Committee, Sabzevar University of Medical Sciences, Sabzevar, Iran.
Sajjad AbbasimoghaddamStudent Research Committee, Sabzevar University of Medical Sciences, Sabzevar, Iran.
Amirhosein ShekartabarStudent Research Committee, Sabzevar University of Medical Sciences, Sabzevar, Iran.
Mohsen HeidaryDepartment of Laboratory Sciences, School of Paramedical Sciences, Sabzevar University of Medical Sciences, Sabzevar, Iran.ORCID https://orcid.org/0000-0002-9839-5017
Saeed KhoshnoodClinical Microbiology Research Center, Ilam University of Medical Sciences, Ilam, Iran.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionThe intensification of coronavirus disease 2019 (COVID-19) complications, severe symptoms, and high mortality rate has led researchers to focus on this significant issue. While respiratory and cardiac complications have been described as high-risk manifestations in patients with COVID-19, neurological complications can also enhance mortality. This study aimed to evaluate the prevalence of neurological complications arises from SARS-CoV-2 and assess the mortality rate from neurological complications. MATERIAL AND

methodsLiterature review was conducted by searching in PubMed/Medline, Web of Sciences, and Embase. After performing search strategies with relevant terms, a number of articles were excluded, including review articles, systematic review or meta-analysis, duplicate publication of same researchers, congress abstracts, animal studies, case reports, case series, and articles reporting a history of neurological features prior to COVID-19 infection. After retrieving the data, statistical analysis was performed using the STATA Version 14 software.

resultsFrom 4455 retrieved publications, 20 articles were selected for further analysis. Among 18,258 included patients, 2791 showed neurological symptoms, which were classified into different groups. Headache, confusion, and fatigue were reported as the most non-specific neurological features in confirmed COVID-19 patients. Psychiatric symptoms, CNS disorders, cerebrovascular disorders, CNS inflammatory disorders, PNS disorders, neuromuscular disorders, etc., were defined as specific neurological manifestations. The pooled prevalence of neurological manifestations and mortality rate of COVID-19 patients with neurological features were estimated to be 23.0% (95% CI: 17.8-29.2) and 29.1% (95% CI: 20.3-39.8), respectively.

conclusionNeurological manifestations may commonly happen in patients with COVID-19. This study reported a high prevalence of neurological complications and mortality rates in COVID-19 patients. Therefore, patients with COVID-19 who indicated neurological symptoms should be taken seriously and should receive early treatment to prevent undesirable events.

Indexed as

Cerebrovascular DisordersCOVID-19Mental DisordersNervous System DiseasesHumansSARS-CoV-2COVID-19nervous systemneurological manifestationsSARS-CoV-2

Identifiers

PMID35385200
PMCPMC9102520

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.