Evidence map›Paper›PMID 35385169›Full record

ArticleThe American journal on addictions2022

Buprenorphine treatment retention and comorbidities among patients with opioid use disorder in a primary care setting.

Mary M Sweeney, Laura Prichett, Michael I Fingerhood, Denis Antoine, Annie Umbricht, Kelly E Dunn, Megan E Buresh

Open access · hybridAbstract read
In one paragraph

Article in The American journal on addictions, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
2.6field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 13 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Mary M SweeneyBehavioral Pharmacology Research Unit, Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.ORCID 0000-0001-6931-4321
Laura PrichettDepartment of Pediatrics, Biostatistics, Epidemiology, and Data Management Core, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.ORCID 0000-0002-6029-6902
Michael I FingerhoodDepartment of Medicine, Division of Addiction Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.ORCID 0000-0002-9594-6215
Denis AntoineBehavioral Pharmacology Research Unit, Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Annie UmbrichtBehavioral Pharmacology Research Unit, Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Kelly E DunnBehavioral Pharmacology Research Unit, Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Megan E BureshDepartment of Medicine, Division of Addiction Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.ORCID 0000-0001-5559-7682
Johns Hopkins University · US

Funding

Substance Use Treatment Linkage Following Brief Intervention in the Emergency Department: Implications for Opioid Use Disorder PatientsR03DA048913 · NIDA · JOHNS HOPKINS UNIVERSITY · PI SWEENEY, MARY MARGARET · 2019 to 2019
$123k
NIDA NIH HHS R03 DA048913
6 · The paper itself

Abstract

BACKGROUND AND 

objectivesMore information is needed about comorbidities among patients receiving buprenorphine maintenance treatment and their relationship with retention.

methodsRetrospective electronic health record data over a 5-year period from primary care patients receiving buprenorphine for the treatment of opioid use disorder were examined (N = 899). The present analysis determined the prevalence of comorbidities and examined associations with treatment retention as defined by cumulative duration of buprenorphine prescription.

resultsTobacco use and comorbidities including hypertension were prevalent but did not predict retention according to survival analyses controlling for demographic characteristics. Retention was poorer among patients testing positive for cocaine (HR = 1.38, 95% CI: 1.09-1.74, p = .007) and patients with hepatitis C virus (HR = 1.17, 95% CI: 1.01-1.37, p = .04). CONCLUSION AND SCIENTIFIC SIGNIFICANCE: This study provides new knowledge of previously unexamined associations between comorbidities (e.g., hypertension) and buprenorphine treatment retention. The robust association between cocaine use and poorer buprenorphine retention serves to resolve prior conflicting data in the literature.

Indexed as

BuprenorphineCocaineHypertensionOpioid-Related DisordersHumansOpiate Substitution TreatmentPrimary Health CareRetrospective StudiesBuprenorphineCocaine

Identifiers

PMID35385169
PMCPMC9117419
OpenAlexW4225910233

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.