Evidence map›Paper›PMID 35385139›Full record

ArticleThe Journal of physiology2022

5-HT7 receptors expressed in the mouse parafacial region are not required for respiratory chemosensitivity.

Yingtang Shi, Cleyton R Sobrinho, Jaseph Soto-Perez, Brenda M Milla, Daniel S Stornetta, Ruth L Stornetta, Ana C Takakura, Daniel K Mulkey, Thiago S Moreira, Douglas A Bayliss

Open access · hybridAbstract read
In one paragraph

Article in The Journal of physiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.7field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
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  5. Revisiting the Role of Serotonin in Sleep-Disordered Breathing.International journal of molecular sciences · 2024
    Review
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  7. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 2 countries.

Yingtang ShiDepartment of Pharmacology, University of Virginia, Charlottesville, VA, USA.
Cleyton R SobrinhoDepartment of Physiology and Biophysics, Institute of Biomedical Science, University of São Paulo, São Paulo, Brazil.ORCID 0000-0002-1472-7169
Jaseph Soto-PerezDepartment of Physiology and Neurobiology, University of Connecticut, Storrs, CT, USA.
Brenda M MillaDepartment of Physiology and Neurobiology, University of Connecticut, Storrs, CT, USA.
Daniel S StornettaDepartment of Pharmacology, University of Virginia, Charlottesville, VA, USA.ORCID 0000-0002-5570-6276
Ruth L StornettaDepartment of Pharmacology, University of Virginia, Charlottesville, VA, USA.ORCID 0000-0001-7278-8923
Ana C TakakuraDepartment of Pharmacology, Institute of Biomedical Science, University of São Paulo, São Paulo, Brazil.ORCID 0000-0001-6273-0760
Daniel K MulkeyDepartment of Physiology and Neurobiology, University of Connecticut, Storrs, CT, USA.ORCID 0000-0002-7040-3927
Thiago S MoreiraDepartment of Physiology and Biophysics, Institute of Biomedical Science, University of São Paulo, São Paulo, Brazil.ORCID 0000-0002-9789-8296
Douglas A BaylissDepartment of Pharmacology, University of Virginia, Charlottesville, VA, USA.ORCID 0000-0002-5630-2572
University of Virginia · USUniversidade de São Paulo · BRUniversity of Connecticut · US

Funding

Retrotrapezoid nucleus and central chemoreceptionR01HL074011 · NHLBI · UNIVERSITY OF VIRGINIA CHARLOTTESVILLE · PI GUYENET, PATRICE G. · 2003 to 2018
$6.6M
Cellular/Molecular Mechanisms of Respiratory Neuronal ChemosensitivityR01HL108609 · NHLBI · UNIVERSITY OF VIRGINIA · PI Douglas A. Bayliss · 2011 to 2026
$6.5M
Role of KCNQ2 Channels in Control of BreathingR01HL137094 · NHLBI · UNIVERSITY OF CONNECTICUT STORRS · PI MULKEY, DANIEL K, TZINGOUNIS, ANASTASIOS · 2018 to 2025
$4.1M
Proposed roles of KCNQ2 Channels in Respiratory HomeostasisF31HL156470 · NHLBI · UNIVERSITY OF CONNECTICUT STORRS · PI SOTO, JASEPH · 2021 to 2024
$173k
Roles of glycinergic neurons in Dravet syndrome-associated disordered breathing and mortalityF31NS120467 · NINDS · UNIVERSITY OF CONNECTICUT STORRS · PI MILLA, BRENDA · 2020 to 2024
$166k
NHLBI NIH HHS F31 HL156470NHLBI NIH HHS R01 HL074011NHLBI NIH HHS R01 HL108609NHLBI NIH HHS R01 HL137094NIH HHS HL074011NIH HHS HL108609NINDS NIH HHS F31 NS120467
6 · The paper itself

Abstract

A brainstem homeostatic system senses CO

Indexed as

Carbon DioxideSerotoninAnimalsChemoreceptor CellsMiceReceptors, SerotoninRespirationCarbon DioxideReceptors, SerotoninSerotoninserotonin 7 receptorbreathingchemosensorCO2Htr7raphe nucleusretrotrapezoidserotonin

Identifiers

PMID35385139
PMCPMC9167793
OpenAlexW4224231582

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.