Evidence map›Paper›PMID 35384956›Full record

ArticleRevista do Instituto de Medicina Tropical de Sao Paulo2022

Silent circulation of Chikungunya virus among pregnant women and newborns in the Western Brazilian Amazon before the first outbreak of chikungunya fever.

Kelly Aparecida Kanunfre, Mussya Cisotto Rocha, Maíra Barreto Malta, Rodrigo Medeiros de Souza, Marcia Caldas Castro, Silvia Beatriz Boscardin, Higo Fernando Santos Souza, Steven S Witkin, Marly Augusto Cardoso, Thelma Suely Okay

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Revista do Instituto de Medicina Tropical de Sao Paulo, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.8field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 4 citations in OpenAlex.

  1. Pattern ofTropical medicine and infectious disease · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 2 countries.

Kelly Aparecida KanunfreUniversidade de São Paulo, Faculdade de Medicina, Instituto de Medicina Tropical de São Paulo, Laboratório de Soroepidemiologia e Imunobiologia, São Paulo, São Paulo, Brazil.ORCID http://orcid.org/0000-0002-1520-4650
Mussya Cisotto RochaUniversidade de São Paulo, Faculdade de Medicina, Instituto de Medicina Tropical de São Paulo, Laboratório de Soroepidemiologia e Imunobiologia, São Paulo, São Paulo, Brazil.ORCID http://orcid.org/0000-0003-3577-1801
Maíra Barreto MaltaUniversidade de São Paulo, Faculdade de Saúde Pública, Departamento de Nutrição, São Paulo, São Paulo, Brazil.ORCID http://orcid.org/0000-0003-4993-1589
Rodrigo Medeiros de SouzaUniversidade Federal do Acre, Campus Floresta, Cruzeiro do Sul, Acre, Brazil.ORCID http://orcid.org/0000-0002-7775-6901
Marcia Caldas CastroHarvard T. H. Chan School of Public Health, Department of Global Health and Population, Boston, Massachusetts, USA.ORCID http://orcid.org/0000-0003-4606-2795
Silvia Beatriz BoscardinUniversidade de São Paulo, Instituto de Ciências Biomédicas, Departamento de Parasitologia, São Paulo, São Paulo, Brazil.ORCID http://orcid.org/0000-0002-7845-7110
Higo Fernando Santos SouzaUniversidade de São Paulo, Instituto de Ciências Biomédicas, Departamento de Parasitologia, São Paulo, São Paulo, Brazil.ORCID http://orcid.org/0000-0002-1095-951X
Steven S WitkinUniversidade de São Paulo, Faculdade de Medicina, Instituto de Medicina Tropical de São Paulo, Laboratório de Virologia (LIM 52), São Paulo, São Paulo, Brazil.ORCID http://orcid.org/0000-0002-3502-3929
Marly Augusto CardosoUniversidade de São Paulo, Faculdade de Saúde Pública, Departamento de Nutrição, São Paulo, São Paulo, Brazil.ORCID http://orcid.org/0000-0003-0973-3908
Thelma Suely OkayUniversidade de São Paulo, Faculdade de Medicina, Instituto de Medicina Tropical de São Paulo, Laboratório de Soroepidemiologia e Imunobiologia, São Paulo, São Paulo, Brazil.ORCID http://orcid.org/0000-0001-9316-7288
Universidade de São Paulo · BRCornell University · USHarvard University · USUniversidade Federal do Acre · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The prevalence of immunity to Chikungunya virus (CHIKV) in pregnant women and newborns in the Western Brazilian Amazon was assessed at a time when previous studies did not report chikungunya fever in the area. In 435 asymptomatic pregnant women and 642 healthy unrelated newborns, the presence of IgM and IgG antibodies to CHIKV were determined by a commercial ELISA. All participants were negative to IgM anti-CHIKV. Anti-CHIKV IgG was identified in 41 (9.4%) pregnant women and 66 (10.3%) newborns. The presence of anti-CHIKV IgG was positively associated with the lowest socioeconomic status in pregnant women (OR 2.54, 95% CI 1.15-5.62, p=0.021) and in the newborns' mothers (OR 5.10, 95% CI 2.15-12.09, p< 0.001). Anti-CHIKV IgG was also associated with maternal age in both, the pregnant women (OR 1.06, 95% CI 1.00-1.11, p=0.037) and the newborns'mothers (OR 1.08, 95% CI 1.03-1.12, p=0.001). Pregnancy outcomes in which the mother or the newborn was anti-CHIKV IgG positive proceeded normally. Negative CHIKV serology was associated with being positive for DENV antibodies and having had malaria during pregnancy. These findings showed that there was already a silent circulation of CHIKV in this Amazon region before the first outbreak of chikungunya fever. Furthermore, seropositivity for CHIKV was surprisingly frequent (10%) in both, pregnant women and newborns, affecting mainly low-income women.

Indexed as

Chikungunya FeverChikungunya virusAntibodies, ViralBrazilFemaleHumansImmunoglobulin GImmunoglobulin MInfant, NewbornPregnancyPregnant PeopleAntibodies, ViralImmunoglobulin GImmunoglobulin M

Identifiers

PMID35384956
PMCPMC8993149
OpenAlexW4226134543

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.