Evidence map›Paper›PMID 35384745›Full record

SynthesisThe American journal of sports medicine2023

One in Three Patients With Chronic Lateral Ankle Instability Has a Cartilage Lesion.

Emma J Wijnhoud, Quinten G H Rikken, Jari Dahmen, Inger N Sierevelt, Sjoerd A S Stufkens, Gino M M J Kerkhoffs

Open access · hybridAbstract readSystematic ReviewMeta-Analysis
In one paragraph

Synthesis in The American journal of sports medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
8.1field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 49 citations in OpenAlex.

  1. Correlation between functional impairment and quantitative MRI assessment of ankle cartilage in chronic ankle instability.Asia-Pacific journal of sports medicine, arthroscopy, rehabilitation and technology · 2026
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  13. [Injuries to the lateral ankle ligaments].Unfallchirurgie (Heidelberg, Germany) · 2025
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Emma J WijnhoudDepartment of Orthopedic Surgery, Amsterdam Movement Sciences, Amsterdam UMC-Location AMC, University of Amsterdam, Amsterdam, the Netherlands.
Quinten G H RikkenDepartment of Orthopedic Surgery, Amsterdam Movement Sciences, Amsterdam UMC-Location AMC, University of Amsterdam, Amsterdam, the Netherlands.ORCID 0000-0002-8134-5419
Jari DahmenDepartment of Orthopedic Surgery, Amsterdam Movement Sciences, Amsterdam UMC-Location AMC, University of Amsterdam, Amsterdam, the Netherlands.
Inger N SiereveltOrthopedic Department, Xpert Clinics, Specialized Center of Orthopedic Research and Education, Amsterdam, the Netherlands.
Sjoerd A S StufkensDepartment of Orthopedic Surgery, Amsterdam Movement Sciences, Amsterdam UMC-Location AMC, University of Amsterdam, Amsterdam, the Netherlands.
Gino M M J KerkhoffsDepartment of Orthopedic Surgery, Amsterdam Movement Sciences, Amsterdam UMC-Location AMC, University of Amsterdam, Amsterdam, the Netherlands.
Academic Center for Evidence-Based Sports Medicine · NLSpaarne Ziekenhuis · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundChronic lateral ankle instability (CLAI) is associated with the presence or development of intra-articular pathologies such as chondral or osteochondral lesions, or (O)CLs. Currently, the incidence of (O)CLs in patients with CLAI is unknown. PURPOSE: To determine the incidence of (O)CLs in patients with CLAI. STUDY

designSystematic review and meta-analysis; Level of evidence, 4.

methodsA literature search was conducted in the PubMed (MEDLINE), Embase (Ovid), and Cochrane databases for articles published from January 2000 until December 2020. Two authors independently screened the search results and conducted the quality assessment using the methodological index for non-randomized studies (MINORS) criteria. Clinical studies were included that reported findings on the presence of ankle (O)CLs based on pre- or intraoperative diagnostic measures in patients with CLAI (>6 months of symptoms). Patient and lesion characteristics were pooled using a simplified method. Lesion characteristics included localization and chondral and osteochondral involvement. The primary outcome was the incidence of (O)CLs in ankles with CLAI. A random-effects model with 95% CIs was used to analyze the primary outcome. The distribution of (O)CLs in the ankle joint was reported according to talar or tibial involvement, with medial and lateral divisions for talar involvement.

resultsTwelve studies were included with 2145 patients and 2170 ankles with CLAI. The pooled incidence of (O)CLs in ankles with CLAI was 32.2% (95% CI, 22.7%-41.7%). Among all lesions, 43% were chondral and 57% were osteochondral. Among all (O)CLs, 85% were located on the talus and 17% on the distal tibia. Of the talar (O)CLs, 68% were located medially and 32% laterally.

conclusion(O)CLs were found in up to 32% of ankles with CLAI. The most common location was the talus (85%). Furthermore, most lesions were located on the medial talar dome (68%). These findings will aid physicians in the early recognition and treatment of ankle (O)CLs in the context of CLAI.

Indexed as

AnkleTalusAnkle JointCartilageHumansTibiaanklechronic lateral ankle instabilityincidenceosteochondral lesion

Identifiers

PMID35384745
PMCPMC10240649
OpenAlexW4226190112

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.