ArticleMaxillofacial plastic and reconstructive surgery2022
The effect of FK506 (tacrolimus) loaded with collagen membrane and fibrin glue on promotion of nerve regeneration in a rat sciatic nerve traction injury model.
Article in Maxillofacial plastic and reconstructive surgery, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 9 citations in OpenAlex.
- Tuning hydrogel properties and Schwann cell behavior through microchannel size control in magnetically templated hydrogels.Biomaterials science · 2026Article
- Localized Tacrolimus Delivery for Peripheral Nerve Regeneration: Molecular Mechanisms, Biomaterial Platforms, and Translational Strategies.International journal of molecular sciences · 2026Review
- Article
- Novelties and limitations of tissue-engineered materials in treating traumatic nerve injuries: a mini review.Frontiers in cell and developmental biology · 2025Review
- [Research progress of silk-based biomaterials for peripheral nerve regeneration].Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery · 2024Review
- A tacrolimus-eluting nerve guidance conduit enhances regeneration in a critical-sized peripheral nerve injury rat model.Biomedical microdevices · 2024Article
- The Effect of Local Purified Exosome Product, Stem Cells, and Tacrolimus on Neurite Extension.The Journal of hand surgery · 2024Article
- Localized tacrolimus therapy: innovations in peripheral nerve regeneration through advanced drug delivery systems.Therapeutic delivery · 2024Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPeripheral nerve injury is one of the most common injuries that might occur in oral and maxillofacial surgery. The purpose of this study was to determine the effect of FK506 loaded with collagen membrane and fibrin glue on the promotion of nerve regeneration after traction nerve injury in a rat model.
methodsThirty male Sprague-Dawley rats were divided into three groups: group A (n = 10), a sham group whose sciatic nerve was exposed without any injury; and groups B (n = 10) and C (n = 10), which underwent traction nerve injury using 200 g of traction force for 1 min. The injured nerve in group C was covered with a collagen membrane soaked with FK506 (0.5 mg/0.1 mL) and fibrin glue. Functional analysis and microscopic evaluation were performed at 2 and 4 weeks after injury.
resultsThe sciatic function index was - 5.78 ± 3.07 for group A, - 20.69 ± 5.22 for group B, and - 12.01 ± 4.20 for group C at 2 weeks after injury. However, at 4 weeks, the sciatic function index was - 5.58 ± 2.45 for group A, - 19.69 ± 4.81 for group B, and - 11.95 ± 1.94 for group C. In both periods, statistically significant differences were found among the groups (p<0.017). Histomorphometric evaluation revealed improved nerve regeneration in group C compared to that in group B. However, no statistical differences in axonal density were found among the three groups (p < 0.017).
conclusionLocalized FK506 with collagen membrane and fibrin glue could promote axonal regeneration in a rat model of traction nerve injury.
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