Evidence map›Paper›PMID 35384588›Full record

ArticleNeuromolecular medicine2022

Interleukin-1 Mediates Ischemic Brain Injury via Induction of IL-17A in γδ T Cells and CXCL1 in Astrocytes.

Ines Sophie Schädlich, Jonas Heinrich Vienhues, Alina Jander, Marius Piepke, Tim Magnus, Kate Lykke Lambertsen, Bettina Hjelm Clausen, Mathias Gelderblom

Open access · hybridAbstract read
In one paragraph

Article in Neuromolecular medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
1.5field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 19 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Macrophage-glia interactions regulate immune damage to enteric neurons during West Nile virus infection.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  5. Review
  6. Modulation of adult hippocampal neurogenesis by interleukin 1 signaling.Neurobiology of sleep and circadian rhythms · 2025
    Article
  7. Article
  8. Article
  9. Review
  10. γδ T cells in immune-mediated kidney disease.European journal of immunology · 2024
    Review
  11. Article
  12. Astrocyte KDM4A mediates chemokines and drives neutrophil infiltration to aggravate cerebral ischemia and reperfusion injury.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2024
    Article
  13. Review
  14. Review
  15. Article
  16. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 2 countries.

Ines Sophie SchädlichDepartment of Neurology, University Medical Center Hamburg-Eppendorf, Martinistrasse 52, 20246, Hamburg-Eppendorf, Germany. i.schaedlich@uke.de.ORCID 0000-0002-9732-7821
Jonas Heinrich VienhuesDepartment of Neurology, University Medical Center Hamburg-Eppendorf, Martinistrasse 52, 20246, Hamburg-Eppendorf, Germany.
Alina JanderDepartment of Neurology, University Medical Center Hamburg-Eppendorf, Martinistrasse 52, 20246, Hamburg-Eppendorf, Germany.
Marius PiepkeDepartment of Neurology, University Medical Center Hamburg-Eppendorf, Martinistrasse 52, 20246, Hamburg-Eppendorf, Germany.
Tim MagnusDepartment of Neurology, University Medical Center Hamburg-Eppendorf, Martinistrasse 52, 20246, Hamburg-Eppendorf, Germany.
Kate Lykke LambertsenDepartment of Neurobiology Research, Institute of Molecular Medicine, University of Southern Denmark, Odense, Denmark.
Bettina Hjelm Clausen *Department of Neurobiology Research, Institute of Molecular Medicine, University of Southern Denmark, Odense, Denmark.
Mathias Gelderblom *Department of Neurology, University Medical Center Hamburg-Eppendorf, Martinistrasse 52, 20246, Hamburg-Eppendorf, Germany.
Universität Hamburg · DEUniversity of Southern Denmark · DK

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

As a prototypical proinflammatory cytokine, interleukin-1 (IL-1) exacerbates the early post-stroke inflammation, whereas its neutralization is protective. To further investigate the underlying cell-type-specific IL-1 effects, we subjected IL-1 (α/β) knockout (Il1

Indexed as

Brain InjuriesStrokeAnimalsAstrocytesChemokine CXCL1Disease Models, AnimalInterleukin-1Interleukin-17MiceMice, Inbred C57BLT-LymphocytesChemokine CXCL1Interleukin-1Interleukin-17AstrocytesCXCL1InflammationInterleukin-1Interleukin-17AIschemic strokeγδ T cells

Identifiers

PMID35384588
PMCPMC9684245
OpenAlexW4226277058

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.