Evidence map›Paper›PMID 35384527›Full record

ArticleCancer causes & control : CCC2022

Analysis of the genomic landscapes of Barbadian and Nigerian women with triple negative breast cancer.

Shawn M Hercules, Xiyu Liu, Blessing B I Bassey-Archibong, Desiree H A Skeete, Suzanne Smith Connell, Adetola Daramola, Adekunbiola A Banjo, Godwin Ebughe, Thomas Agan, Ima-Obong Ekanem and 19 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancer causes & control : CCC, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
0.8field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
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  3. Evolutionary Restructuring and Systematic Review of theJournal of developmental biology · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

29 authors at 13 institutions in 6 countries.

Shawn M HerculesDepartment of Biology, McMaster University, Hamilton, ON, Canada.
Xiyu LiuDepartment of Translational Genomics, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Blessing B I Bassey-ArchibongStem Cell and Cancer Research Institute (SCC-RI), McMaster University, Hamilton, ON, Canada.
Desiree H A SkeeteAfrican Caribbean Cancer Consortium, Philadelphia, PA, USA.
Suzanne Smith ConnellFaculty of Medical Sciences, University of the West Indies at Cave Hill, Bridgetown, Barbados.
Adetola DaramolaDepartment of Anatomic and Molecular Pathology, Lagos University Teaching Hospital, Lagos, Nigeria.
Adekunbiola A BanjoDepartment of Anatomic and Molecular Pathology, Lagos University Teaching Hospital, Lagos, Nigeria.
Godwin EbugheDepartment of Pathology, University of Calabar Teaching Hospital, Calabar, Nigeria.
Thomas AganDepartment of Obstetrics & Gynaecology, College of Medical Sciences, University of Calabar Teaching Hospital, Calabar, Nigeria.
Ima-Obong EkanemDepartment of Pathology, College of Medical Sciences, University of Calabar Teaching Hospital, Calabar, Nigeria.
Joe UdosenDivision of General and Breast Surgery, University of Calabar Teaching Hospital, Calabar, Nigeria.
Christopher ObiorahDepartment of Anatomical Pathology, University of Port Harcourt Teaching Hospital, Port Harcourt, Nigeria.
Aaron C OjuleDepartment of Chemical Pathology, University of Port Harcourt Teaching Hospital, Port Harcourt, Nigeria.
Michael A MisaunoDepartment of Surgery, Jos University Teaching Hospital, Jos, Nigeria.
Ayuba M DaudaDepartment of Pathology, Jos University Teaching Hospital, Jos, Nigeria.
Ejike C EgbujoMeena Histopathology and Cytology Laboratory, Jos, Nigeria.
Jevon C HerculesDepartment of Mathematics, University of the West Indies at Mona, Kingston, Jamaica.
Amna AnsariDepartment of Biology, McMaster University, Hamilton, ON, Canada.
Ian BrainDepartment of Pathology and Molecular Medicine, McMaster University, Hamilton, ON, Canada.
Christine MacCollDepartment of Pathology and Molecular Medicine, McMaster University, Hamilton, ON, Canada.
Yili XuDepartment of Translational Genomics, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Yuxin JinDepartment of Translational Genomics, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Sharon ChangDepartment of Translational Genomics, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
John D CarptenDepartment of Translational Genomics, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
André BédardDepartment of Biology, McMaster University, Hamilton, ON, Canada.
Greg R PondDepartment of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, ON, Canada.
Kim R M BlenmanDepartment of Internal Medicine, Section of Medical Oncology, Yale Cancer Center, School of Medicine, New Haven, CT, USA.
Zarko ManojlovicDepartment of Translational Genomics, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Juliet M DanielDepartment of Biology, McMaster University, Hamilton, ON, Canada. danielj@mcmaster.ca.ORCID http://orcid.org/0000-0002-3497-0772
University of Southern California · USMcMaster University · CAUniversity of Calabar · NGJos University Teaching Hospital · NGLagos University Teaching Hospital · NGUniversity of Port Harcourt Teaching Hospital · NGCancer Research Institute · USImpact · CAMichigan Cancer Research Consortium · USRoss University School of Medicine · BBUniversity of the West Indies · BBUniversity of the West Indies System · JMYale Cancer Center · US

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
Canadian Breast Cancer Foundation/Canadian Cancer Society Research Institute 316252CIHR PJT-173223Natural Sciences and Engineering Research Council of Canada RGPIN-2020-06822NCATS NIH HHS UL1 TR001863
6 · The paper itself

Abstract

purposeTriple negative breast cancer (TNBC) is an aggressive breast cancer subtype that disproportionately affects women of African ancestry (WAA) and is often associated with poor survival. Although there is a high prevalence of TNBC across West Africa and in women of the African diaspora, there has been no comprehensive genomics study to investigate the mutational profile of ancestrally related women across the Caribbean and West Africa.

methodsThis multisite cross-sectional study used 31 formalin-fixed paraffin-embedded (FFPE) samples from Barbadian and Nigerian TNBC participants. High-resolution whole exome sequencing (WES) was performed on the Barbadian and Nigerian TNBC samples to identify their mutational profiles and comparisons were made to African American, European American and Asian American sequencing data obtained from The Cancer Genome Atlas (TCGA). Whole exome sequencing was conducted on tumors with an average of 382 × coverage and 4335 × coverage for pooled germline non-tumor samples.

resultsVariants detected at high frequency in our WAA cohorts were found in the following genes NBPF12, PLIN4, TP53 and BRCA1. In the TCGA TNBC cases, these genes had a lower mutation rate, except for TP53 (32% in our cohort; 63% in TCGA-African American; 67% in TCGA-European American; 63% in TCGA-Asian). For all altered genes, there were no differences in frequency of mutations between WAA TNBC groups including the TCGA-African American cohort. For copy number variants, high frequency alterations were observed in PIK3CA, TP53, FGFR2 and HIF1AN genes.

conclusionThis study provides novel insights into the underlying genomic alterations in WAA TNBC samples and shines light on the importance of inclusion of under-represented populations in cancer genomics and biomarker studies.

Indexed as

Triple Negative Breast NeoplasmsBarbadosCross-Sectional StudiesFemaleGenomicsHumansMutationNigeriaGenomicsTriple negative breast cancerWhole exome sequencingWomen of African ancestry

Identifiers

PMID35384527
PMCPMC9085672
OpenAlexW4226107291

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.