ArticleZeitschrift fur Rheumatologie2023
[Chronic Tropheryma whipplei infection: an important differential diagnosis of refractory polyarthritis].
Article in Zeitschrift fur Rheumatologie, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed, 13 citations in OpenAlex.
- [Histopathological diagnostics of infections in rheumatology].Zeitschrift fur Rheumatologie · 2025Review
- [Reactive arthritis].Zeitschrift fur Rheumatologie · 2025Review
- ExploringFrontiers in pharmacology · 2025Article
- Two cases demonstrate an association between Tropheryma whipplei and pulmonary marginal zone lymphoma.Infectious agents and cancer · 2024Article
- Recovery of hearing loss, depression and erosive polyarthritis after diagnosis of Whipple's disease.Rheumatology advances in practice · 2023Article
- Design of a Multi-Epitope Vaccine againstVaccines · 2022Article
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundRefractory arthritis is a common problem in routine rheumatology practice, and can be a diagnostic challenge. In these cases, chronic Tropheryma whipplei (T. whipplei) infection is an important differential diagnosis that should be considered.
objectiveBased on five clinical cases, this case-based review describes the diagnostic and therapeutic principles in the management of chronic T. whipplei infection.
resultsWhipple's disease is a multisystemic infectious disease caused by the bacterium T. whipplei. The disease typically manifests with arthralgia, weight loss and diarrhoea. Joint involvement often develops years before gastrointestinal symptoms occur. In addition to systemic manifestations ("classic Whipple's disease"), T. whipplei can also lead to localized joint infections without gastrointestinal involvement. Articular manifestations of systemic and localized T. whipplei infections are commonly misdiagnosed as a sign of various forms of autoimmmune arthritis. DISCUSSION: Whipple's disease and localized T. whipplei joint infection should be considered in the diagnostic work-up of refractory arthritis. Synovial fluid analysis by means of specific polymerase chain reaction-based testing for T. whipplei is diagnostically ground-breaking.
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