ArticleCancer medicine2022
Associations of systemic inflammation markers with identification of pulmonary nodule and incident lung cancer in Chinese population.
Article in Cancer medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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Who cites it
33 citing papers in PubMed.
- Preliminary Effects of Hydrogen-Oxygen Inhalation on Nodule Size, IL-6, and Neutrophils in Patients with Small Pulmonary Nodules.Drug design, development and therapy · 2026Trial
- Systemic immune-inflammatory index is associated with malignancy in Lung-RADS 4 lung nodules.Journal of thoracic disease · 2026Article
- From Local Tissue Repair to Fibrosis: Deciphering Gene Co-Expression Networks in Benign Pulmonary Nodules and Idiopathic Pulmonary Fibrosis Comorbidity via Bioinformatics and Machine Learning.International journal of molecular sciences · 2026Article
- Research status and progress on the relationship between obstructive sleep apnea and pulmonary nodules.Frontiers in medicine · 2026Review
- Associations of derived inflammatory, lipid, and anthropometric indices with CT-detected pulmonary nodules: a hospital-based cross-sectional study with explainable machine learning.Frontiers in endocrinology · 2026Article
- Clinical significance of the systemic immune-inflammation index in relation to pathology, treatment and outcomes in acute appendicitis: a retrospective study.Annals of medicine · 2025Article
- Role of Systemic Inflammatory Markers in the Differential Diagnosis of Organizing Pneumonia and Lung Cancer.APMIS : acta pathologica, microbiologica, et immunologica Scandinavica · 2025Article
- Predictive value of systemic inflammatory indices for perinatal outcomes following cervical cerclage: a retrospective cohort study.BMC pregnancy and childbirth · 2025Article
- Predictive value of inflammatory indices for disease severity and perinatal outcomes in intrahepatic cholestasis of pregnancy.BMC pediatrics · 2025Article
- Application of liquid biopsy in differentiating lung cancer from benign pulmonary nodules (Review).International journal of molecular medicine · 2025Review
- An integrated proteomic classifier to distinguish benign from malignant pulmonary nodules.Clinical proteomics · 2025Article
- Long-term consumption of green tea protects the mental health of middle-aged and older adult men by improving inflammation levels.Frontiers in public health · 2025Article
- Systemic immune inflammatory index and mortality in chronic kidney disease.Frontiers in endocrinology · 2025Article
- Assessment of extracellular vesicle microRNAs detection in predicting benign and malignant pulmonary ground glass nodules.Frontiers in medicine · 2025Article
- Differentiating Pulmonary Nodule Malignancy Using Exhaled Volatile Organic Compounds: A Prospective Observational Study.Cancer medicine · 2025Observational
- Article
- The predictive value of serum inflammatory markers for the severity of cervical lesions.BMC cancer · 2024Article
- Saliva‑microbiome‑derived signatures: expected to become a potential biomarker for pulmonary nodules (MCEPN-1).BMC microbiology · 2024Article
- Protective effect of avicularin against lung cancer via inhibiting inflammation, oxidative stress, and induction of apoptosis: an in vitro and in vivo study.In vitro cellular & developmental biology. Animal · 2024Article
- Association of blood cell-based inflammatory markers with gut microbiota and cancer incidence in the Rotterdam study.Cancer medicine · 2024Article
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13 authors.
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Abstract
objectivesNeutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and systemic immune-inflammation index (SII), easily accessible systemic inflammation response parameters, were reported to associate with poor lung cancer prognosis. However, research on the effects of these markers on the risk of positive nodules (PNs) and lung cancer is limited.
methodsParticipants in this retrospective study were those who had their first computed tomography (CT) screening at Jiangsu Province Hospital's Health Promotion Center between January 1, 2017 and December 31, 2020. We identified PNs (≥6 mm in diameter) from free text of CT reports and lung cancer from medical records. Multivariate logistic analysis was used to assess the association between NLR, PLR, or SII and PNs or lung cancer.
resultsThe detected rate of PNs was 9.60% among the 96,476 participants. Age, smoking and body mass index were possible influencing factors for PNs. We observed linear dose-effect relationship between NLR, PLR, or SII and PNs (p
conclusionsThe high levels of systemic inflammation markers were associated with the risk of positive pulmonary nodules and lung cancer, which suggested systemic immune response may be an important pre-clinical feature for the early identification of diseases.
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