ArticlePhysiological reports2022
The role of activation of two different sGC binding sites by NO-dependent and NO-independent mechanisms in the regulation of SACs in rat ventricular cardiomyocytes.
Article in Physiological reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 14 citations in OpenAlex.
- Hypergravity Enhances Stretch Sensitivity in Rat Cardiomyocytes via Increased Expression and Activity of Stretch-Activated Channels.International journal of molecular sciences · 2025Article
- Hypergravity Increases and Simulated Microgravity Decreases the Ion Current through Mechanically Gated Channels during Stretching of Isolated Rat Cardiomyocytes.Bulletin of experimental biology and medicine · 2025Article
- Simulated Microgravity Attenuates Stretch Sensitivity of Mechanically Gated Channels in Rat Ventricular Myocytes.International journal of molecular sciences · 2025Article
- Simulated Microgravity and Hypergravity Affect the Expression Level of Soluble Guanylate Cyclase, Adenylate Cyclase, and Phosphodiesterase Genesin Rat Ventricular Cardiomyocytes.Bulletin of experimental biology and medicine · 2024Article
- Transcriptomic profile of the mechanosensitive ion channelome in human cardiac fibroblasts.Experimental biology and medicine (Maywood, N.J.) · 2023Article
- Identification of RNA reads encoding different channels in isolated rat ventricular myocytes and the effect of cell stretching on L-type CaBiology direct · 2023Article
- Hypergravity Increases the Number of Gene Transcripts of Mechanically Gated and Mechanosensitive Ion Channels in Rat Ventricular Cardiomyocytes.Bulletin of experimental biology and medicine · 2023Article
- Development of a Method for Isolation of Mature Cardiomyocytes from Human Heart Biopsy Specimens.Bulletin of experimental biology and medicine · 2023Article
- Tetrahydrocurcumin-Related Vascular Protection: An Overview of the Findings from Animal Disease Models.Molecules (Basel, Switzerland) · 2022Review
- The role of activation of two different sGC binding sites by NO-dependent and NO-independent mechanisms in the regulation of SACs in rat ventricular cardiomyocytes.Physiological reports · 2022Article
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Authors and funding
9 authors at 2 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The mechanoelectrical feedback (MEF) mechanism in the heart that plays a significant role in the occurrence of arrhythmias, involves cation flux through cation nonselective stretch-activated channels (SACs). It is well known that nitric oxide (NO) can act as a regulator of MEF. Here we addressed the possibility of SAC's regulation along NO-dependent and NO-independent pathways, as well as the possibility of S-nitrosylation of SACs. In freshly isolated rat ventricular cardiomyocytes, using the patch-clamp method in whole-cell configuration, inward nonselective stretch-activated cation current I
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