ArticleEuropean journal of neurology2022
Tracheostomy is associated with increased survival in Multiple System Atrophy patients with stridor.
Article in European journal of neurology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.
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Who cites it
10 citing papers in PubMed, 1 synthesis or guideline pooled it, 20 citations in OpenAlex.
- A strategic approach of the management of sleep-disordered breathing in multiple system atrophy.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2025Pooled it
- Paroxysmal dyspnea in multiple system atrophy: a case of severe floppy arytenoid.Acta neurologica Belgica · 2026Article
- Stridor Is an Independent Risk Factor for Mortality and Disease Progression in Patients with Multiple System Atrophy.Movement disorders : official journal of the Movement Disorder Society · 2026Article
- Review
- Trends in Invasive Interventions and Risk Factors for Early Critical Events in Multiple System Atrophy.Cerebellum (London, England) · 2025Article
- Impact of supine body position on sleep-disordered breathing in patients with MSA patients.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2025Article
- Early-onset dysphagia predicts short survival in multiple system atrophy.Journal of neurology · 2024Article
- Neurological update: the palliative care landscape for atypical parkinsonian syndromes.Journal of neurology · 2023Article
- Multiple system atrophy laryngeal stridor treated with radiofrequency-assisted posterior cordotomy and arytenoidectomy.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2022Article
- Tracheostomy is associated with increased survival in Multiple System Atrophy patients with stridor.European journal of neurology · 2022Article
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
background and purposeStridor treatment in multiple system atrophy (MSA) mainly comprises tracheostomy or continuous positive airway pressure (CPAP), but guidelines for the use of these treatments are lacking. The aim of the study was to evaluate the predictive value of stridor treatment in an MSA cohort.
methodsThis is a retrospective and prospective monocentric cohort study including MSA patients evaluated at least once a year during the disease course. Stridor was video-polysomnography confirmed. The time of stridor treatment (CPAP or tracheostomy) and latency from stridor onset were collected. Survival and predictors of survival were calculated.
resultsA total of 182 (107 males, mean age at disease onset 57.3 ± 8.4 years) MSA patients were included in the study; 141 were deceased at the time of study. Of the total sample, 75 patients were diagnosed with stridor: 22 patients were treated with tracheostomy and 29 with CPAP, whilst 24 patients did not receive treatment. Treatment with tracheostomy showed longer survival compared with both treatment with CPAP or no treatment (incidence rate of death 12 vs. 21 vs. 23 per 100 person-years, respectively). Tracheostomy remained an independent factor associated with longer survival (hazard ratio 0.38, p = 0.029), also after adjustment for other confounders and latency for stridor treatment.
conclusionsThis is the largest monocentric and long-term follow-up study comparing survival between tracheostomy and CPAP in MSA patients with stridor. Treatment with tracheostomy showed longer survival compared with both treatment with CPAP or no treatment. A careful multidisciplinary approach is required for the management of MSA patients with stridor.
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