ArticleHuman brain mapping2022
Two distinct subtypes of obsessive compulsive disorder revealed by heterogeneity through discriminative analysis.
Article in Human brain mapping, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 3 of them syntheses that pooled it.
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Who cites it
21 citing papers in PubMed, 3 syntheses or guidelines pooled it, 42 citations in OpenAlex.
- Common and distinct neural patterns of gray matter alterations in adults with anorexia nervosa and obsessive-compulsive disorder.European archives of psychiatry and clinical neuroscience · 2025Pooled it
- A comprehensive review for machine learning on neuroimaging in obsessive-compulsive disorder.Frontiers in human neuroscience · 2023Pooled it
- The therapeutic alliance in cognitive-behavioral therapy for obsessive-compulsive disorder: A systematic review and meta-analysis.Frontiers in psychiatry · 2022Pooled it
- Developmental coupling between obsessive-compulsive symptoms and psychotic-like experiences in youth: a four-wave longitudinal study.Scientific reports · 2026Article
- Recent developments in imaging transcriptomics for psychiatric disorders.Psychoradiology · 2026Review
- Two subtypes of major depressive disorder are identified from individualized gray matter morphological abnormalities in a large multi-site dataset.Psychological medicine · 2025Article
- Common neuroanatomical differential factors underlying heterogeneous gray matter volume variations in five common psychiatric disorders.Communications biology · 2025Article
- Individualized resting-state functional connectivity abnormalities unveil two major depressive disorder subtypes with contrasting abnormal patterns of abnormality.Translational psychiatry · 2025Article
- Analysis of Two Neuroanatomical Subtypes of Parkinson's Disease and Their Motor Progression Based on Semi-Supervised Machine Learning.CNS neuroscience & therapeutics · 2025Article
- Individualized gray matter morphological abnormalities unveil two neuroanatomical obsessive-compulsive disorder subtypes.Translational psychiatry · 2025Article
- Artificial Intelligence in Obsessive-Compulsive Disorder: A Systematic Review.Current treatment options in psychiatry · 2025Review
- Metaanalysis of Repetitive Transcranial Magnetic Stimulation (rTMS) Efficacy for OCD Treatment: The Impact of Stimulation Parameters, Symptom Subtype and rTMS-Induced Electrical Field.Journal of clinical medicine · 2024Review
- Elucidating Multimodal Imaging Patterns in Accelerated Brain Aging: Heterogeneity through a Discriminant Analysis Approach Using the UK Biobank Dataset.Bioengineering (Basel, Switzerland) · 2024Article
- Two distinct neuroanatomical subtypes of migraine without aura revealed by heterogeneity through discriminative analysis.Brain imaging and behavior · 2023Article
- Mapping the neuroanatomical heterogeneity of OCD using a framework integrating normative model and non-negative matrix factorization.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- Two distinct subtypes of obsessive compulsive disorder revealed by heterogeneity through discriminative analysis.Human brain mapping · 2022Article
- Structural and Functional Brain Changes in Patients With Classic Trigeminal Neuralgia: A Combination of Voxel-Based Morphometry and Resting-State Functional MRI Study.Frontiers in neuroscience · 2022Article
- Higher brain structural heterogeneity in schizophrenia.Frontiers in psychiatry · 2022Article
- Distinct profiles of functional connectivity density aberrance in Alzheimer's disease and mild cognitive impairment.Frontiers in psychiatry · 2022Article
- Suicidal Ideation and Obsessive-Compulsive Disorder: Links and Knowledge.Psychology research and behavior management · 2022Review
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Neurobiological heterogeneity in obsessive compulsive disorder (OCD) is understudied leading to conflicting neuroimaging findings. Therefore, we investigated objective neuroanatomical subtypes of OCD by adopting a newly proposed method based on gray matter volumes (GMVs). GMVs were derived from T1-weighted anatomical images of patients with OCD (n = 100) and matched healthy controls (HCs; n = 106). We first inquired whether patients with OCD presented higher interindividual variability HCs in terms of GMVs. Then, we identified distinct subtypes of OCD by adopting heterogeneity through discriminative analysis (HYDRA), where regional GMVs were treated as features. Patients with OCD presented higher interindividual variability than HCs, suggesting a high structural heterogeneity of OCD. HYDRA identified two distinct robust subtypes of OCD presenting opposite neuroanatomical aberrances compared with HCs, while sharing indistinguishable clinical and demographic features. Specifically, Subtype 1 exhibited widespread increased GMVs in cortical and subcortical regions, including the orbitofrontal gyrus, right anterior insula, bilateral hippocampus, and bilateral parahippocampus and cerebellum. Subtype 2 demonstrated overall decreased GMVs in regions such as the orbitofrontal gyrus, right anterior insula, and precuneus. When mixed together, none of patients presented significant differences compared with HCs. In addition, the total intracranial volume of Subtype 2 was significantly correlated with the total score of the Yale-Brown Obsessive Compulsive Scale while that of Subtype 1 was not. These results identified two distinct neuroanatomical subtypes, providing a possible explanation for conflicting neuroimaging findings, and proposed a potential objective taxonomy contributing to precise clinical diagnosis and treatment in OCD.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.