Evidence map›Paper›PMID 35384030›Full record

ReviewAmerican journal of hematology2022

Tyrosine Kinase Inhibitor discontinuation in Chronic Myeloid Leukemia: eligibility criteria and predictors of success.

Elena Inzoli, Andrea Aroldi, Rocco Piazza, Carlo Gambacorti-Passerini

Abstract readReview
In one paragraph

Review in American journal of hematology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed.

  1. Article
  2. Article
  3. Real World Outcomes with Treatment Free Remission in Chronic Myeloid Leukemia-Experience from a Tertiary Care Cancer Centre.Indian journal of hematology & blood transfusion : an official journal of Indian Society of Hematology and Blood Transfusion · 2024
    Article
  4. Article
  5. Article
  6. Review
  7. Article
  8. Review
  9. Article
  10. Review
  11. Article
  12. Article
  13. Article
  14. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Elena InzoliDepartment of Medicine and Surgery, University of Milano-Bicocca, Milano, Italy.ORCID 0000-0002-0315-6065
Andrea AroldiDepartment of Medicine and Surgery, University of Milano-Bicocca, Milano, Italy.
Rocco PiazzaDepartment of Medicine and Surgery, University of Milano-Bicocca, Milano, Italy.
Carlo Gambacorti-PasseriniDepartment of Medicine and Surgery, University of Milano-Bicocca, Milano, Italy.ORCID 0000-0001-6058-515X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

TKI discontinuation proved to be safe and feasible in patients with CML with deep and durable molecular responses, introducing an additional treatment goal for these patients beyond overall survival. However, treatment interruption is a safe procedure only with appropriate patient selection and monitoring. Clinical and biological factors associated with better outcomes do not yet offer a precise stratification of patients according to their risk of relapse. This article aims at reviewing the leading studies present in the field in order to define eligibility criteria for discontinuation and predictors of success.

Indexed as

Leukemia, Myelogenous, Chronic, BCR-ABL PositiveHumansPatient SelectionProtein Kinase InhibitorsRecurrenceProtein Kinase Inhibitors

Identifiers

PMID35384030
PMCPMC9546318

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.