Evidence map›Paper›PMID 35383912›Full record

ArticleEpilepsia2022

COVID-19 vaccine in patients with Dravet syndrome: Observations and real-world experiences.

Veronica Hood, Anne T Berg, Kelly G Knupp, Sookyong Koh, Linda Laux, Mary Anne Meskis, Quratulain Zulfiqar-Ali, M Scott Perry, Ingrid E Scheffer, Joseph Sullivan and 2 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Epilepsia, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
2.7field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it, 20 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Article
  6. Review
  7. Article
  8. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors at 11 institutions in 3 countries.

Veronica HoodDravet Syndrome Foundation, Cherry Hill, New Jersey, USA.ORCID 0000-0002-1988-4980
Anne T BergDepartment of Neurology, Northwestern Feinberg School of Medicine, Chicago, Illinois, USA.ORCID 0000-0002-0298-5523
Kelly G KnuppDepartment of Pediatrics and Neurology, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA.ORCID 0000-0002-1967-0827
Sookyong KohDepartment of Pediatric Neurology at University of Nebraska Medical Center, Omaha, Nebraska, USA.
Linda LauxEpilepsy Center, Department of Pediatrics, Ann & Robert H. Lurie Children's Hospital, Chicago, Illinois, USA.
Mary Anne MeskisDravet Syndrome Foundation, Cherry Hill, New Jersey, USA.
Quratulain Zulfiqar-AliAdult Epilepsy Genetics Program, Krembil Brain Institute, Toronto Western Hospital, Toronto, Ontario, Canada.ORCID 0000-0002-3984-5276
M Scott PerryJane and John Justin Neurosciences Center, Cook Children's Medical Center, Fort Worth, Texas, USA.ORCID 0000-0002-1825-846X
Ingrid E SchefferEpilepsy Research Centre, University of Melbourne, Austin Health; Royal Children's Hospital, Florey Institute; Murdoch Children's Research Institute, Melbourne, Victoria, Australia.ORCID 0000-0002-2311-2174
Joseph SullivanDepartments of Neurology and Pediatrics, University of California, San Francisco, San Francisco, California, USA.
Elaine WirrellChild and Adolescent Neurology, Mayo Clinic, Rochester, Minnesota, USA.ORCID 0000-0003-3015-8282
Danielle M AndradeDravet Syndrome Foundation, Cherry Hill, New Jersey, USA.ORCID 0000-0003-0953-2698
Dravet Syndrome Foundation · USCook Children's Medical Center · USLurie Children's Hospital · USMayo Clinic in Florida · USNebraska Medical Center · USNorthwestern University · USRoyal Children's Hospital · AUToronto Western Hospital · CAUniversity of California, San Francisco · USUniversity of Colorado Anschutz Medical Campus · USUniversity of Toronto · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveVaccination against the SARS-CoV-2 virus is a primary tool to combat the COVID-19 pandemic. However, vaccination is a common seizure trigger in individuals with Dravet syndrome (DS). Information surrounding COVID-19 vaccine side effects in patients with DS would aid caregivers and providers in decisions for and management of COVID-19 vaccination.

methodsA survey was emailed to the Dravet Syndrome Foundation's Family Network and posted to the Dravet Parent & Caregiver Support Group on Facebook between May and August 2021. Deidentified information obtained included demographics and vaccination status for individuals with DS. Vaccine type, side effects, preventative measures, and changes in seizure activity following COVID-19 vaccination were recorded. For unvaccinated individuals, caregivers were asked about intent to vaccinate and reasons for their decision.

resultsOf 278 survey responses, 120 represented vaccinated individuals with DS (median age = 19.5 years), with 50% reporting no side effects from COVID-19 vaccination. Increased seizures following COVID-19 vaccination were reported in 16 individuals, but none had status epilepticus. Of the 158 individuals who had not received a COVID-19 vaccination, 37 were older than 12 years (i.e., eligible at time of study), and only six of these caregivers indicated intent to seek vaccination. The remaining 121 responses were caregivers to children younger than 12 years, 60 of whom indicated they would not seek COVID-19 vaccination when their child with DS became eligible. Reasons for vaccine hesitancy were fear of increased seizure activity and concerns about vaccine safety. SIGNIFICANCE: These results indicate COVID-19 vaccination is well tolerated by individuals with DS. One main reason for vaccine hesitancy was fear of increased seizure activity, which occurred in only 13% of vaccinated individuals, and none had status epilepticus. This study provides critical and reassuring insights for caregivers and health care providers making decisions about the safety of COVID-19 vaccinations for individuals with DS.

Indexed as

COVID-19Epilepsies, MyoclonicStatus EpilepticusAdultChildCOVID-19 VaccinesEpileptic SyndromesHumansPandemicsSARS-CoV-2SeizuresSpasms, InfantileVaccinationYoung AdultCOVID-19 VaccinesCOVID-19Dravetsurveyvaccine

Identifiers

PMID35383912
PMCPMC9111612
OpenAlexW4224282297

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.